KCNK2 - potassium two pore domain channel subfamily K member 2 Gene

中文名称：钾二孔域通道亚科 K 成员 2

种属: Homo sapiens

同用名: TREK; TPKC1; TREK1; K2p2.1; TREK-1; hTREK-1c; hTREK-1e

基因 ID: 3776 | 基因类型: protein coding

关于 KCNK2

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:215,005,542-215,237,090 (from NCBI)

This gene has 9 transcripts (splice variants), 282 orthologues and 14 paralogues. Biased expression in adrenal (RPKM 18.5), thyroid (RPKM 2.6) and 1 other tissue.

功能概要

该基因编码双孔结构域背景钾通道蛋白家族的成员之一。这种类型的钾通道由两个同型二聚体形成，这两个同型二聚体形成一个通道，将钾从细胞中泄漏出来，以控制静息膜电位。然而，该通道可以通过某些麻醉剂、膜拉伸、细胞内酸中毒和加热来打开。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

This gene encodes one of the members of the two-pore-domain background Potassium Channel protein family. This type of Potassium Channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

KCNK2 基因产物(3)

mRNA	Protein	Name
NM_001017424.3	NP_001017424.1	potassium channel subfamily K member 2 isoform a
NM_001017425.3	NP_001017425.2	potassium channel subfamily K member 2 isoform c
NM_014217.4	NP_055032.1	potassium channel subfamily K member 2 isoform b

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables mechanosensitive potassium channel activity	IDA IDA: 通过直接分析推断	38605031	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KCNK2 蛋白结构

Ion_trans_2

0
100
200
300
400
426 a.a.

蛋白主名

其他名称

potassium channel subfamily K member 2

K2P2.1 potassium channel

关联疾病

疾病名称

别名

Dentin Sensitivity

Sensitive Dentin

Birk-Barel Syndrome

Birk-Barel Mental Retardation Dysmorphism Syndrome	BIBARS
Mental Retardation With Hypotonia And Facial Dysmorphism	Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome
Kcnk9 Imprinting Syndrome

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2x

Lgmd2x

Muscular Dystrophy, Limb-Girdle, Type 2x

Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema

Dehydrated Hereditary Stomatocytosis	Hereditary Xerocytosis
Xerocytosis, Hereditary	Pshk1
Pseudohyperkalemia Edinburgh	Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/Or Perinatal Edema
DHS1	Dhs
Hereditary Desiccytosis	Dehydrated Hereditary Stomatocytosis 1
Desiccytosis, Hereditary	Pseudohyperkalemia, Familial, 1, Due To Red Cell Leak
Pseudohyperkalemia Familial 1, Due To Red Cell Leak	Desiccytosis Hereditary
Xerocytosis Hereditary	Familial Pseudohyperkalemia 1 Due To Red Cell Leak
Stomatocytosis, Dehydrated, Hereditary, With/Without Pseudohyperkalemia And/Or Perinatal Edema	Xerocytosis

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-B1500	2,2,2-Trichloroethanol	Agonist	99.53%	否
HY-RS07158	KCNK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS18069	Kcnk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24544	Kcnk2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	KCNK2	RGD	RGD:621448
Bos taurus	KCNK2	VGNC	VGNC:30472
Macaca mulatta	KCNK2	VGNC	VGNC:99988
Felis catus	KCNK2	VGNC	VGNC:67920
Mus musculus	KCNK2	MGD	MGI:109366
Canis familiaris	KCNK2	VGNC	VGNC:42274

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KCNK2 - potassium two pore domain channel subfamily K member 2 Gene

关于 KCNK2

功能概要

KCNK2 基因产物(3)

KCNK2 蛋白结构

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

KCNK2 - potassium two pore domain channel subfamily K member 2 Gene

关于 KCNK2

功能概要

KCNK2 基因产物(3)

KCNK2 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z