KCNMB1 - potassium calcium-activated channel subfamily M regulatory beta subunit 1 Gene

中文名称：钾钙激活通道亚家族 M 调节 β 亚基 1

种属: Homo sapiens

同用名: hbeta1; BKbeta1; SLO-BETA; hslo-beta; K(VCA)beta; slo-beta-1; k(VCA)beta-1

基因 ID: 3779 | 基因类型: protein coding

关于 KCNMB1

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:170,374,671-170,389,367 (from NCBI)

This gene has 2 transcripts (splice variants), 129 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in endometrium (RPKM 43.3), prostate (RPKM 41.0) and 15 other tissues.

功能概要

MaxiK 通道是大电导、电压和钙敏感的钾通道，它们是控制平滑肌张力和神经元兴奋性的基础。 MaxiK 通道可由 2 个亚基形成：成孔 α 亚基和该基因的产物，即调节性 β 亚基。细胞内钙调节 α 和 β 亚基之间的物理联系。[RefSeq 提供，2008 年 7 月]

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008]

KCNMB1 基因产物(1)

mRNA	Protein	Name
NM_004137.4	NP_004128.1	calcium-activated potassium channel subunit beta-1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KCNMB1 蛋白结构

CaKB

0
100
191 a.a.

蛋白主名

其他名称

calcium-activated potassium channel subunit beta-1

BK channel beta subunit 1

关联疾病

疾病名称

别名

Hypertension, Diastolic

Hypertension, Diastolic, Resistance To

Diastolic Hypertension

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Long Qt Syndrome 1

Romano-Ward Syndrome	LQT1
Ward-Romano Syndrome	Rws
Ventricular Fibrillation With Prolonged Qt Interval	Wrs
Long Qt Syndrome 1, Acquired, Susceptibility To	Long Qt Syndrome 1, Acquired
Romano-Ward Long Qt Syndrome	Long Qt Syndrome Type 1
Long Qt Syndrome-1	Acquired Susceptibility To Long Qt Syndrome 1
Qt Syndrome, Long, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-W396714	Succinic acid sodium	Inhibitor	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07165	KCNMB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	KCNMB1	MGD	MGI:1334203
Bos taurus	KCNMB1	VGNC	VGNC:30480
Rattus norvegicus	KCNMB1	RGD	RGD:2961
Felis catus	KCNMB1	VGNC	VGNC:102239
Macaca mulatta	KCNMB1	VGNC	VGNC:73999
Canis familiaris	KCNMB1	VGNC	VGNC:42282

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KCNMB1 - potassium calcium-activated channel subfamily M regulatory beta subunit 1 Gene

关于 KCNMB1

功能概要

KCNMB1 基因产物(1)

KCNMB1 蛋白结构

关联疾病

直系同源

热门区域

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KCNMB1 - potassium calcium-activated channel subfamily M regulatory beta subunit 1 Gene

关于 KCNMB1

功能概要

KCNMB1 基因产物(1)

KCNMB1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z