2. Gene
  3. Nefh - neurofilament, heavy polypeptide Gene

Nefh - neurofilament, heavy polypeptide Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Nfh; NF-H; NF200; mKIAA0845

基因 ID: 380684 | 基因类型: protein coding

关于 Nefh

功能概要

A structural constituent of postsynaptic intermediate filament Cytoskeleton. Involved in axon development. Acts upstream of or within cellular response to leukemia inhibitory factor; Cytoskeleton organization; and peripheral nervous system neuron axonogenesis. Located in several cellular components, including Schaffer collateral - CA1 synapse; intermediate filament cytoskeleton; and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2CC; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 1; and monoclonal gammopathy of uncertain significance. Orthologous to human NEFH (neurofilament heavy chain). [provided by Alliance of Genome Resources, Apr 2022]

Nefh 基因产物(1)

mRNA Protein Name
NM_010904.3 NP_035034.2 neurofilament heavy polypeptide
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables structural constituent of postsynaptic intermediate filament cytoskeleton IDA
IDA: 通过直接分析推断
25869803 MGI
enables structural constituent of postsynaptic intermediate filament cytoskeleton IMP
IMP: 通过突变表型推断
25869803 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in axon development IMP
IMP: 通过突变表型推断
9763431 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: 通过表达模式推断
20439489 MGI
acts upstream of or within intermediate filament bundle assembly IGI
IGI: 通过遗传相互作用推断
10461886 MGI
acts upstream of or within intermediate filament cytoskeleton organization IMP
IMP: 通过突变表型推断
14561875 MGI
acts upstream of or within microtubule cytoskeleton organization IGI
IGI: 通过遗传相互作用推断
10461886 MGI
acts upstream of or within neurofilament cytoskeleton organization IGI
IGI: 通过遗传相互作用推断
10461886 MGI
acts upstream of or within neurofilament cytoskeleton organization IMP
IMP: 通过突变表型推断
20633607 MGI
acts upstream of or within peripheral nervous system neuron axonogenesis IMP
IMP: 通过突变表型推断
20633607 MGI
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
25869803 MGI
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
25869803 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
25869803 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
25869803 MGI
located in axon IDA
IDA: 通过直接分析推断
8110465 MGI
located in neurofilament IDA
IDA: 通过直接分析推断
10221457 MGI
located in postsynaptic density IDA
IDA: 通过直接分析推断
17114649 MGI
is active in postsynaptic intermediate filament cytoskeleton IDA
IDA: 通过直接分析推断
25869803 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neurofilament heavy polypeptide

200 kDa neurofilament protein

neurofilament 200kDa

neurofilament triplet H protein

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09183 NEFH Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22249 Nefh Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28771 Nefh Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nefh NCBI NCBI:4744
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