2. Gene
  3. Parl - presenilin associated, rhomboid-like Gene

Parl - presenilin associated, rhomboid-like Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Psarl; PSARL1; PRO2207; PSENIP2; D16Ertd607e

基因 ID: 381038 | 基因类型: protein coding

关于 Parl

功能概要

Enables endopeptidase activity. Involved in several processes, including mitochondrial fusion; negative regulation of apoptotic signaling pathway; and regulation of Autophagy of mitochondrion. Located in mitochondrial inner membrane. Used to study Leigh disease. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; coronary artery disease; hyperinsulinism; myopia; and type 2 diabetes mellitus. Orthologous to human PARL (presenilin associated rhomboid like). [provided by Alliance of Genome Resources, Apr 2022]

Parl 基因产物(2)

mRNA Protein Name
NM_001005767.4 NP_001005767.1 presenilins-associated rhomboid-like protein, mitochondrial precursor
NM_001005767.4 NP_001005767.1 presenilins-associated rhomboid-like protein, mitochondrial precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables endopeptidase activity IMP
IMP: 通过突变表型推断
21138942 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
18288109 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mitochondrial fusion IMP
IMP: 通过突变表型推断
16713954 MGI
involved in negative regulation of intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
16839884 MGI
involved in negative regulation of release of cytochrome c from mitochondria IMP
IMP: 通过突变表型推断
16839884 MGI
involved in proteolysis IGI
IGI: 通过遗传相互作用推断
21426348 MGI
involved in proteolysis IMP
IMP: 通过突变表型推断
21138942 MGI
involved in regulation of mitophagy IMP
IMP: 通过突变表型推断
21355049 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial inner membrane IMP
IMP: 通过突变表型推断
16839884 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

presenilins-associated rhomboid-like protein, mitochondrial

mitochondrial intramembrane-cleaving protease PARL

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-152265A PARL-IN-1 TFA Activator / Phase 2
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-169380 PARL-IN-2 / 否
HY-152265 PARL-IN-1 Activator / 否
HY-176347S Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2 / 否
HY-RS10044 PARL Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18365 Parl Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24844 Parl Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Parl NCBI NCBI:55486
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