KLKB1 - kallikrein B1 Gene

中文名称：激肽释放酶 B1

种属: Homo sapiens

同用名: PKK; PPK; KLK3; PKKD

基因 ID: 3818 | 基因类型: protein coding

关于 KLKB1

Cytogenetic location: 4q35.2 Genomic coordinates (GRCh38): 4:186,210,853-186,258,471 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues, 16 paralogues and is associated with 2 phenotypes. Biased expression in liver (RPKM 44.5) and kidney (RPKM 1.2).

功能概要

该基因编码一种糖蛋白，参与血液凝固、纤维蛋白溶解、激肽生成和炎症的表面依赖性激活。编码的前原蛋白作为具有高分子量激肽原的非共价复合物存在于血浆中，经过由活化的凝血因子 XII 介导的蛋白水解加工，产生由重链和轻链组成的二硫键连接的异二聚丝氨酸蛋白酶。该基因的某些突变会导致前激肽释放酶缺乏症。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2016 年 1 月]

This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

KLKB1 基因产物(3)

mRNA	Protein	Name
NM_000892.5	NP_000883.2	plasma kallikrein isoform 1 preproprotein
NM_001318394.2	NP_001305323.1	plasma kallikrein isoform 2
NM_001318396.2	NP_001305325.1	plasma kallikrein isoform 3 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	2844223	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in plasminogen activation	IDA IDA: 通过直接分析推断	89876	GOA
involved in positive regulation of fibrinolysis	IDA IDA: 通过直接分析推断	89876	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	89876	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KLKB1 蛋白结构

PAN_1

Trypsin

0
100
200
300
400
500
600
638 a.a.

蛋白主名

其他名称

plasma kallikrein

kallikrein B, plasma (Fletcher factor) 1

KLKB1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	KLKB1	P03952	TMEM185A	Homo sapiens	Q8NFB2	Y2H Pooling	32814053
种属内	KLKB1	P03952	TMEM185A	Homo sapiens	Q8NFB2	Validated Y2H	32814053
种属内	KLKB1	P03952	TMEM185A	Homo sapiens	Q8NFB2	Y2H Array	32814053
种属内	KLKB1	P03952	NPHP1	Homo sapiens	C9J082	Validated Y2H	32814053
种属内	KLKB1	P03952	NPHP1	Homo sapiens	C9J082	Y2H Array	32814053
种属内	KLKB1	P03952	NPHP1	Homo sapiens	C9J082	Y2H Pooling	32814053
种属内	KLKB1	P03952	TGOLN2	Homo sapiens	O43493-5	Validated Y2H	32814053
种属内	KLKB1	P03952	TGOLN2	Homo sapiens	O43493-5	Y2H Pooling	32814053
种属内	KLKB1	P03952	TGOLN2	Homo sapiens	O43493-5	Y2H Array	32814053
种属内	KLKB1	P03952	SLFN12	Homo sapiens	Q8IYM2	Validated Y2H	32814053
种属内	KLKB1	P03952	SLFN12	Homo sapiens	Q8IYM2	Y2H Pooling	32814053
种属内	KLKB1	P03952	SLFN12	Homo sapiens	Q8IYM2	Y2H Array	32814053
种属内	KLKB1	P03952	PRMT5	Homo sapiens	O14744	Validated Y2H	32814053
种属内	KLKB1	P03952	PRMT5	Homo sapiens	O14744	Y2H Array	32814053
种属内	KLKB1	P03952	PRMT5	Homo sapiens	O14744	Y2H Pooling	32814053
种属内	KLKB1	P03952	NME4	Homo sapiens	O00746	Y2H Array	32814053
种属内	KLKB1	P03952	NME4	Homo sapiens	O00746	Validated Y2H	32814053
种属内	KLKB1	P03952	NME4	Homo sapiens	O00746	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 KLKB1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70249	Plasma kallikrein/KLKB1 Protein, Human (HEK293, His, solution)	P03952 (G20-A638)	≥95%

KLKB1 抗体

目录号	产品名	应用	反应物种
HY-P83618	Plasma Kallikrein Antibody (YA3363)	WB, IHC-P, IP	Human, Rat

关联疾病

疾病名称

别名

Prekallikrein Deficiency

Fletcher Factor Deficiency	PKK DEFICIENCY
Fletcher Factor Deficiency	Congenital Prekallikrein Deficiency
PKKD	Fletcher Trait

Hereditary Angioedema

Hereditary Angioneurotic Edema	Hereditary Angioedema Type 1
Hane	Angioedema, Hereditary
Hae	Angioedemas, Hereditary
Deficiency Of C1 Esterase Inhibitor	C1 Esterase Inhibitor Deficiency
C1 Inhibitor Deficiency	Familial Angioneurotic Edema
Hereditary Bradykinine-Induced Angioedema	Hereditary Non Histamine-Induced Angioedema
Hae 1	Hae-I
Hereditary Angioneurotic Edema Type 1	Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor
Hereditary Angioedema Types I And Ii	Hereditary Angioneurotic Oedema
Familial Angioedema	Hae - [Hereditary Angioneurotic Oedema]
Bannister Disease, Hereditary	Quincke Disease Or Oedema
Hereditary Quincke Oedema

Angioedema

Angioneurotic Oedema	Quincke'S Edema
Angioneurotic Edema	Giant Urticaria

High Molecular Weight Kininogen Deficiency

HMWK DEFICIENCY	Fitzgerald Trait
Congenital High-Molecular-Weight Kininogen Deficiency	Flaujeac Factor Deficiency
Kininogen Deficiency, High Molecular Weight	Kininogen Deficiency
Hmwk	High-Molecular-Weight Kininogen Deficiency, Congenital

Renal Hypertension

Hypertension Renal

Hypertension, Renal

C1 Inhibitor Deficiency

Quincke Edema	Angioedemas, Hereditary
Angioedema

Pyruvate Kinase Deficiency Of Red Cells

Pyruvate Kinase Deficiency	Pk Deficiency
Pyruvate Kinase Deficiency Of Erythrocyte	Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
Pyruvate Kinase Deficiency Of Erythrocytes	Pkd
PKRD	Hereditary Non-Spherocytic Hemolytic Anemia Due To Pyruvate Kinase Deficiency
Hnsha	Pyruvate Kinase-Deficient Hemolytic Anemia
Red Cell Pyruvate Kinase Deficiency	Deficiency Of Pyruvate Kinase
Anemia, Hemolytic, Congenital Nonspherocytic

Acquired Angioedema

Acquired C1 Inhibitor Deficiency	Angioedema, Acquired
Aae	Acquired Angioneurotic Edema
Acquired Bradykinine-Induced Angioedema	Acquired Non Histamine-Induced Angioedema
Acquired Angioneurotic Oedema	Aae - [Acquired Angioneurotic Oedema]

Congenital Nonspherocytic Hemolytic Anemia

Hereditary Non-Spherocytic Hemolytic Anemia	Hereditary Nonspherocytic Hemolytic Anemia
Anemia, Hemolytic, Congenital Nonspherocytic	Congenital Nonspherocytic Hemolytic Anaemia
Hereditary Nonspherocytic Hemolytic Anaemia	Hnsha

Liver Cirrhosis

Cirrhosis	Cirrhosis Of Liver
CIRRH	Cryptogenic Cirrhosis
Cirrhosis, Cryptogenic	Cirrhosis Nos

Angioedema, Hereditary, 1

Hereditary Angioedema Type I	Hereditary Angioneurotic Edema
Hane	C1 Esterase Inhibitor Deficiency
Angioedema, Hereditary, 1 And 2	HAE1
Angioneurotic Edema, Hereditary	Angioedema, Hereditary, Type I
Hereditary Angioedema Type 2	Hae 2
Hae-Ii	Hereditary Angioneurotic Edema Type 2
Angioedema, Hereditary	HAE
Angioedema, Hereditary, Types I And Ii	Hereditary Angioedema, Type Ii
Angioedema, Hereditary, Type 1	Angioedemas, Hereditary
Hereditary C1 Esterase Inhibitor Deficiency - Dysfunctional Factor	Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor
Hereditary Angioedema Types I And Ii

Factor Xii Deficiency

Hageman Factor Deficiency	Haf Deficiency
Factor Xii Deficiency Disease	F12 Deficiency
Deficiency, Hageman	Coagulation Factor 12 Deficiency
Factor 12 Deficiency	Congenital Factor Xii Deficiency
Congenital Hageman Factor Deficiency	FA12D
Factor Xii	Deficiency, Factor Xii

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Microvascular Complications Of Diabetes 5

Diabetic Retinopathy	Microvascular Complications Of Diabetes, Susceptibility To, 5
MVCD5	Retinopathy, Diabetic
Diabetic Nephropathy	Retinopathy, Diabetic, Susceptibility To
Retinal Abnormality - Diabetes-Related

Diabetic Macular Edema

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-148949A	Kallikrein 5-IN-2 TFA	Inhibitor	99.53%	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	KLKB1	VGNC	VGNC:74195
Rattus norvegicus	KLKB1	RGD	RGD:67382
Bos taurus	KLKB1	VGNC	VGNC:30683
Felis catus	KLKB1	VGNC	VGNC:67969
Canis familiaris	KLKB1	VGNC	VGNC:42484
Mus musculus	KLKB1	MGD	MGI:102849
Macaca fascicularis	KLKB1	NCBI	NCBI:102142369
Others	KLKB1	NCBI

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站点地图隐私声明

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KLKB1 - kallikrein B1 Gene

关于 KLKB1

功能概要

KLKB1 基因产物(3)

KLKB1 蛋白结构

KLKB1 蛋白互作信息

重组 KLKB1 蛋白

KLKB1 抗体

关联疾病

直系同源

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KLKB1 - kallikrein B1 Gene

关于 KLKB1

功能概要

KLKB1 基因产物(3)

KLKB1 蛋白结构

KLKB1 蛋白互作信息

重组 KLKB1 蛋白

KLKB1 抗体

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

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Q

S

T

X

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