2. Gene
  3. Unc13a - unc-13 homolog A Gene

Unc13a - unc-13 homolog A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Munc13-1; 2410078G03Rik

基因 ID: 382018 | 基因类型: protein coding

关于 Unc13a

功能概要

Enables diacylglycerol binding activity. Involved in several processes, including positive regulation of glutamate receptor signaling pathway; positive regulation of synaptic plasticity; and synaptic vesicle exocytosis. Acts upstream of or within several processes, including amyloid-beta metabolic process; chemical synaptic transmission; and modulation of chemical synaptic transmission. Located in calyx of Held and neuromuscular junction. Is active in glutamatergic synapse and presynaptic active zone. Is expressed in nervous system and neural retina. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human UNC13A (unc-13 homolog A). [provided by Alliance of Genome Resources, Apr 2022]

Unc13a 基因产物(1)

mRNA Protein Name
NM_001029873.2 NP_001025044.2 protein unc-13 homolog A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calmodulin binding IDA
IDA: 通过直接分析推断
31787876 MGI
enables diacylglycerol binding IDA
IDA: 通过直接分析推断
15123597 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10488064 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within amyloid-beta metabolic process IMP
IMP: 通过突变表型推断
15123597 MGI
NOT involved in dense core granule docking IGI
IGI: 通过遗传相互作用推断
26575293 MGI
acts upstream of or within innervation IGI
IGI: 通过遗传相互作用推断
15988013 MGI
acts upstream of or within neuromuscular junction development IGI
IGI: 通过遗传相互作用推断
15988013 MGI
involved in neuronal dense core vesicle exocytosis IMP
IMP: 通过突变表型推断
23229896 MGI
acts upstream of neurotransmitter secretion IMP
IMP: 通过突变表型推断
11792326 MGI
involved in positive regulation of glutamate receptor signaling pathway IMP
IMP: 通过突变表型推断
23070049 MGI
acts upstream of or within positive regulation of neurotransmitter secretion IMP
IMP: 通过突变表型推断
11792326 MGI
involved in positive regulation of synaptic plasticity IGI
IGI: 通过遗传相互作用推断
23658173 MGI
involved in regulation of amyloid precursor protein catabolic process IMP
IMP: 通过突变表型推断
23070049 MGI
acts upstream of or within regulation of short-term neuronal synaptic plasticity IMP
IMP: 通过突变表型推断
11832228 MGI
acts upstream of or within synaptic transmission, glutamatergic IGI
IGI: 通过遗传相互作用推断
11792326 MGI
acts upstream of or within synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
11832228 MGI
acts upstream of or within synaptic vesicle docking IGI
IGI: 通过遗传相互作用推断
19558619 MGI
involved in synaptic vesicle exocytosis IDA
IDA: 通过直接分析推断
10440375 MGI
involved in synaptic vesicle exocytosis IMP
IMP: 通过突变表型推断
10440375 MGI
acts upstream of or within synaptic vesicle maturation IMP
IMP: 通过突变表型推断
10440375 MGI
involved in synaptic vesicle priming IMP
IMP: 通过突变表型推断
11832228 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
23791195 MGI
is active in calyx of Held IDA
IDA: 通过直接分析推断
23658173 MGI
located in calyx of Held IDA
IDA: 通过直接分析推断
23658173 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
10440375 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
10440375 MGI
located in neuromuscular junction IDA
IDA: 通过直接分析推断
15988013 MGI
located in presynapse IDA
IDA: 通过直接分析推断
25609709 MGI
is active in presynaptic active zone IDA
IDA: 通过直接分析推断
23658173 MGI
located in presynaptic active zone IDA
IDA: 通过直接分析推断
23658173 MGI
located in synapse IDA
IDA: 通过直接分析推断
23791195 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein unc-13 homolog A

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15464 UNC13A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21216 Unc13a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27732 Unc13a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Unc13a NCBI NCBI:23025
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z