2. Gene
  3. SUMO4 - small ubiquitin like modifier 4 Gene

SUMO4 - small ubiquitin like modifier 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：小泛素样修饰符 4

种属: Homo sapiens

同用名: IDDM5; SMT3H4; SUMO-4; dJ281H8.4

基因 ID: 387082 | 基因类型: protein coding

关于 SUMO4

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,400,262-149,401,278 (from NCBI)

This gene has 1 transcript (splice variant), 90 orthologues, 3 paralogues and is associated with 1 phenotype.

功能概要

该基因是 SUMO 基因家族的成员。该基因家族编码小的泛素相关修饰物，这些修饰物附着在蛋白质上并控制目标蛋白质的亚细胞定位、稳定性或活性。该记录中描述的蛋白质位于细胞质中并特异性修饰 IKBA，导致 IL12B 基因的 NF-kappa-B 依赖性转录的负调节。这种导致 M55V 替换的 SUMO 基因的特定多态性与 I 型糖尿病有关。 RefSeq 包含这种多态性。[RefSeq 提供，2008 年 7 月]

This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]

SUMO4 基因产物(1)

mRNA Protein Name
NM_001002255.2 NP_001002255.1 small ubiquitin-related modifier 4
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to oxidative stress IDA
IDA: 通过直接分析推断
16236267 GOA
involved in negative regulation of DNA binding IDA
IDA: 通过直接分析推断
16236267 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15247916 GOA
involved in positive regulation of DNA binding IDA
IDA: 通过直接分析推断
16236267 GOA
involved in protein sumoylation IDA
IDA: 通过直接分析推断
15247916 GOA
involved in regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
15247916 GOA
involved in regulation of protein localization to nucleus IDA
IDA: 通过直接分析推断
16236267 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SUMO ligase complex IDA
IDA: 通过直接分析推断
16236267 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SUMO4 蛋白结构

Rad60-SLD

Rad60-SLD: Ubiquitin-2 like Rad60 SUMO-like (18 - 86)

  • 0
  • 95 a.a.
蛋白主名 其他名称

small ubiquitin-related modifier 4

SMT3 suppressor of mif two 3 homolog 2

SUMO4 抗体

目录号 产品名 应用 反应物种
HY-P82876 SUMO4 Antibody (YA2621) WB, ICC/IF, IP, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Type 1 Diabetes Mellitus 5

Diabetes Mellitus, Insulin-Dependent, 5

Latent Autoimmune Diabetes In Adults

IDDM5

Insulin-Dependent Diabetes Mellitus 5

T1D5

Lada

Type 1.5 Diabetes

Diabetes Mellitus, Insulin-Dependent, Type 5
Diabetes Mellitus

Diabetes
Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent

Diabetes Mellitus Type 1

IDDM

Type 1 Diabetes

Insulin-Dependent Diabetes Mellitus

T1D

Juvenile-Onset Diabetes

Jod

Diabetes Mellitus, Type 1

Diabetes Mellitus, Insulin-Dependent-1

Type I Diabetes Mellitus

Autoimmune Diabetes

Juvenile Diabetes

Juvenile-Onset Diabetes Mellitus

Diabetes, Insulin Dependent

Insulin-Dependent Diabetes Mellitus-1

Diabetes Mellitus Insulin-Dependent

Diabetes Autoimmune

Diabetes Mellitus, Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 1, Susceptibility To

Diabetes Type 1

Type I Diabetes

Diabetes, Autoimmune

T1dm - [Type 1 Diabetes Mellitus]

Iddm - [Insulin Dependent Diabetes Mellitus]

Type 1 Iddm

Juvenile Diabetes Mellitus Without Compications

Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

Juvenile-Onset Diabetes Mellitus Without Compications

Ketosis-Prone Diabetes Mellitus Without Compications

Juvenile-Onset-Type Diabetes Mellitus Without Compications
Meier-Gorlin Syndrome 8

MGORS8
Parkinson Disease 7, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 7

PARK7

Parkinson'S Disease 7

Autosomal Recessive Early-Onset Parkinson'S Disease 7

Parkinson Disease 7

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Type 2

Autosomal Recessive Early-Onset Parkinson Disease Type 7

Parkinson Disease, Type 7
Type 1 Diabetes Mellitus 2

Diabetes Mellitus, Noninsulin-Dependent, 1

Diabetes Mellitus, Insulin-Dependent, 2

IDDM2

Insulin-Dependent Diabetes Mellitus 2

NIDDM1

Diabetes Mellitus, Noninsulin-Dependent 1

T1D2

Type 2 Diabetes Mellitus 1

T2D1

Noninsulin-Dependent Diabetes Mellitus 1

Diabetes Mellitus, Non-Insulin-Dependent, 1

Type 2 Diabetes Mellitus 1, Susceptibility To

Diabetes Mellitus, Insulin-Dependent, Type 2

Diabetes Mellitus, Non-Insulin-Dependent
Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behçet'S Disease

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14028 SUMO4 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SUMO4 RGD RGD:41241227
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