ARHGDIB - Rho GDP dissociation inhibitor beta Gene

中文名称：Rho GDP 解离抑制因子β

种属: Homo sapiens

同用名: D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; RhoGDI2

关于 ARHGDIB

功能概要

Rho (或 ARH) 蛋白家族成员 (参见 MIM 165390) 和其他 Ras 相关小 GTP 结合蛋白 (参见 MIM 179520) 参与多种细胞事件，包括细胞信号传导、增殖、细胞骨架组织和分泌。 GTP 结合蛋白仅在 GTP 结合状态下有活性。至少有 3 类蛋白质严格调节 GTP 结合状态和 GDP 结合状态之间的循环：GTP 酶激活蛋白 (GAP) 、鸟嘌呤核苷酸释放因子 (GRF) 和 GDP 解离抑制剂 (GDI) 。包括 ARHGDIB 在内的 GDI 降低了 GDP 与 Ras 样 GTP 酶的解离速率 (Scherle 等人总结，1993 [PubMed 8356058]) 。[OMIM 提供，2010 年 12 月]

Members of the Rho (or ARH) protein family (see MIM 165390) and Other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]