LLGL2 - LLGL scribble cell polarity complex component 2 Gene

中文名称：LLGL scribble 细胞极性复数组分 2

种属: Homo sapiens

同用名: HGL; LGL2; Hugl-2

关于 LLGL2

功能概要

果蝇的致死 (2) 巨型幼虫蛋白在不对称细胞分裂、上皮细胞极性和细胞迁移中发挥作用。这种人类基因编码的蛋白质类似于果蝇的致死 (2) 巨型幼虫。在飞行中，蛋白质定位细胞命运决定因素的能力受非典型蛋白激酶 C (aPKC) 调节。在人类中，这种蛋白质与含有 aPKC 的复合物相互作用，并定位于有丝分裂细胞的皮质。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]