PRSS57 - serine protease 57 Gene

中文名称：丝氨酸蛋白酶 57

种属: Homo sapiens

同用名: NSP4; PRSSL1; UNQ782

基因 ID: 400668 | 基因类型: protein coding

关于 PRSS57

This gene has 2 transcripts (splice variants), 114 orthologues and 14 paralogues. Restricted expression toward bone marrow (RPKM 54.0).

功能概要

该基因编码精氨酸特异性丝氨酸蛋白酶和肽酶 S1 蛋白家族的成员。编码的蛋白质在储存在免疫系统的嗜中性粒细胞中的天青粒细胞之前可能会经历蛋白水解激活。在中性粒细胞激活后，蛋白酶被释放到细胞周围环境中，在那里它可能在防御微生物病原体中发挥作用。[RefSeq 提供，2016 年 7 月]

This gene encodes an arginine-specific serine protease and member of the peptidase S1 family of proteins. The encoded protein may undergo proteolytic activation before storage in azurophil granules, in neutrophil cells of the immune system. Following neutrophil activation, the protease is released into the pericellular environment, where it may play a role in defense against microbial pathogens. [provided by RefSeq, Jul 2016]

PRSS57 基因产物(2)

mRNA	Protein	Name
NM_001308209.2	NP_001295138.2	serine protease 57 isoform 2 precursor
NM_214710.5	NP_999875.2	serine protease 57 isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables heparin binding	IDA IDA: 通过直接分析推断	25156428	GOA
enables serine-type peptidase activity	IDA IDA: 通过直接分析推断	25156428	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in proteolysis	IDA IDA: 通过直接分析推断	22474388	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in azurophil granule lumen	IDA IDA: 通过直接分析推断	23904161	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	22474388	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRSS57 蛋白结构

Trypsin

0
100
200
283 a.a.

蛋白主名

其他名称

serine protease 57

neutrophil serine protease 4

关联疾病

疾病名称

别名

Eastern Equine Encephalitis

Eee	Neuroinvasive Eastern Equine Encephalitis Virus Infection
Eastern Equine Encephalomyelitis	Encephalomyelitis, Eastern Equine
Triple E	Eastern Equine Encephalitis Virus Infection
Neuroinvasive Eastern Equine Encephalitis Virus Disease	Eee - [Eastern Equine Encephalitis]

Western Equine Encephalitis

Western Equine Encephalomyelitis	Wee
Encephalomyelitis, Western Equine	Western Equine Encephalitis Virus Infection
Wee - [Western Equine Encephalitis]	Western Equine Encephalitis Virus

Osmotic Diarrhea

Acute Diarrhea

Secretory Diarrhea

Venezuelan Equine Encephalitis

Venezuelan Equine Fever	Venezuelan Equine Encephalomyelitis
Encephalitis Venezuelan Equine	Encephalomyelitis, Venezuelan Equine
Venezuelan Encephalitis	Disorder Due To Venezuelan Equine Encephalitis Virus
Venezuelan Equine Encephalitis Virus Infection	Venezuelan Equine Encephalomyelitis Virus Disease

Papillon-Lefevre Syndrome

Papillon-Lefevre Disease	Papillon-Lefèvre Syndrome
PLS	Keratosis Palmoplantaris With Periodontopathia
PALS	Papillon Lefevre Syndrome
Keratosis Palmoplantar-Periodontopathy Syndrome	Papillon-Lefvre Syndrome
Hyperkeratosis Palmoplantaris With Periodontosis	Keratoris Palmoplantaris With Periodontopathia
Keratosis Palmoplantar - Periodontopathy	Palmar-Plantar Hyperkeratosis And Concomitant Periodontal Destruction
Palmoplantar Keratoderma With Periodontosis	Palsy

Noonan Syndrome 4

NS4	Noonan Syndrome, Type 4

Griscelli Syndrome, Type 3

Griscelli Syndrome Type 3	GS3
Griscelli-Prunieras Syndrome Type 3	Hypomelanosis With No Immunologic Or Neurologic Manifestations
Griscelli Syndrome 3

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11258	PRSS57 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS21915	Prss57 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	PRSS57	VGNC	VGNC:64403
Bos taurus	PRSS57	VGNC	VGNC:33425
Macaca mulatta	PRSS57	VGNC	VGNC:76352
Rattus norvegicus	PRSS57	RGD	RGD:1303330
Canis familiaris	PRSS57	VGNC	VGNC:54343
Mus musculus	PRSS57	MGD	MGI:1920356

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PRSS57 - serine protease 57 Gene

关于 PRSS57

功能概要

PRSS57 基因产物(2)

PRSS57 蛋白结构

关联疾病

直系同源

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PRSS57 - serine protease 57 Gene

关于 PRSS57

功能概要

PRSS57 基因产物(2)

PRSS57 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z