2. Gene
  3. LPP - LIM domain containing preferred translocation partner in lipoma Gene

LPP - LIM domain containing preferred translocation partner in lipoma Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 LIM 域脂肪瘤中的首选易位伙伴

种属: Homo sapiens

基因 ID: 4026 | 基因类型: protein coding

关于 LPP

Cytogenetic location: 3q27.3-q28 Genomic coordinates (GRCh38): 3:188,153,021-188,890,671 (from NCBI)

This gene has 22 transcripts (splice variants), 200 orthologues, 1 paralogue and is associated with 85 phenotypes. Ubiquitous expression in endometrium (RPKM 14.7), esophagus (RPKM 14.3) and 24 other tissues.

功能概要

该基因编码 LIM 结构域蛋白亚家族的成员，其特征在于 N 末端富含脯氨酸的区域和三个 C 末端 LIM 结构域。编码的蛋白质定位于粘着斑的细胞外围，可能参与细胞间粘附和细胞运动。这种蛋白质也穿梭于细胞核中，并可作为转录共激活因子发挥作用。该基因位于某些与疾病相关的染色体易位的连接处，从而导致可能促进肿瘤生长的嵌合蛋白的表达。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 7 月]

This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

LPP 基因产物(35)

mRNA Protein Name
NM_001167671.3 NP_001161143.1 lipoma-preferred partner isoform a
NM_001167672.3 NP_001161144.1 lipoma-preferred partner isoform b
NM_001375455.1 NP_001362384.1 lipoma-preferred partner isoform a
NM_001375456.1 NP_001362385.1 lipoma-preferred partner isoform a
NM_001375457.1 NP_001362386.1 lipoma-preferred partner isoform a
NM_001375458.1 NP_001362387.1 lipoma-preferred partner isoform a
NM_001375459.1 NP_001362388.1 lipoma-preferred partner isoform a
NM_001375460.1 NP_001362389.1 lipoma-preferred partner isoform a
NM_001375461.1 NP_001362390.1 lipoma-preferred partner isoform a
NM_001375462.1 NP_001362391.1 lipoma-preferred partner isoform a
NM_001375463.1 NP_001362392.1 lipoma-preferred partner isoform a
NM_001375464.1 NP_001362393.1 lipoma-preferred partner isoform a
NM_001375465.1 NP_001362394.1 lipoma-preferred partner isoform a
NM_001387663.1 NP_001374592.1 lipoma-preferred partner isoform a
NM_001387664.1 NP_001374593.1 lipoma-preferred partner isoform a
NM_001387665.1 NP_001374594.1 lipoma-preferred partner isoform a
NM_001387666.1 NP_001374595.1 lipoma-preferred partner isoform a
NM_001387667.1 NP_001374596.1 lipoma-preferred partner isoform a
NM_001387668.1 NP_001374597.1 lipoma-preferred partner isoform a
NM_001387669.1 NP_001374598.1 lipoma-preferred partner isoform a
NM_001387670.1 NP_001374599.1 lipoma-preferred partner isoform a
NM_001387671.1 NP_001374600.1 lipoma-preferred partner isoform a
NM_001387672.1 NP_001374601.1 lipoma-preferred partner isoform a
NM_001387673.1 NP_001374602.1 lipoma-preferred partner isoform a
NM_001387674.1 NP_001374603.1 lipoma-preferred partner isoform a
NM_001387675.1 NP_001374604.1 lipoma-preferred partner isoform c
NM_001387676.1 NP_001374605.1 lipoma-preferred partner isoform c
NM_001387677.1 NP_001374606.1 lipoma-preferred partner isoform d
NM_001387678.1 NP_001374607.1 lipoma-preferred partner isoform d
NM_001387679.1 NP_001374608.1 lipoma-preferred partner isoform d
NM_001387680.1 NP_001374609.1 lipoma-preferred partner isoform d
NM_001387681.1 NP_001374610.1 lipoma-preferred partner isoform d
NM_001387682.1 NP_001374611.1 lipoma-preferred partner isoform d
NM_001387683.1 NP_001374612.1 lipoma-preferred partner isoform d
NM_005578.5 NP_005569.1 lipoma-preferred partner isoform a

LPP 蛋白结构

LIM

LIM: LIM domain (416 - 471)

LIM

LIM: LIM domain (476 - 532)

LIM

LIM: LIM domain (536 - 596)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 612 a.a.
蛋白主名 其他名称

lipoma-preferred partner

LIM protein

关联疾病

疾病名称 别名
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Acute Monoblastic Leukemia

Acute Monocytic Leukemia

Acute Myeloblastic Leukemia Type 5

Aml M5

Aml-M5

M5b Acute Differentiated Monocytic Leukemia

Acute Monocytic/Monoblastic Leukemia
Lipomatosis, Multiple

Lipoma

Familial Multiple Lipomatosis

Lipomatosis, Familial Multiple

Benign Lipomatous Tumor

Lipomatous Neoplasm

Multiple Lipomatosis

Fml

Lipo

Benign Tumor Of Adipose Tissue

Lipomatous Tumor

Tumor Of Adipose Tissue

Neoplasms, Adipose Tissue

Lipomas
Soft Tissue Chondroma

Extraskeletal Chondroma
Pneumonic Plague

Primary Pneumonic Plague

Secondary Pneumonic Plague

Plague

Plague, Pneumonic

Plague Pneumonia

Plague Of Lung

Pulmonary Plague

Pneumonia Due To Yersinia Pestis
Primary Central Nervous System Lymphoma

Pcnsl

Primary Cns Lymphoma

Primary Brain Lymphoma

Primary Lymphoma, Cns

Primary Cerebral Lymphoma
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Prostate Carcinoma In Situ

Carcinoma In Situ Of Prostate

Grade Iii Pin

Pin Iii
Retinitis Pigmentosa 71

RP71

Retinitis Pigmentosa, Type 71
Infiltrating Lipoma

Intramuscular Lipoma
Esophageal Atresia

Tracheoesophageal Fistula

Congenital Atresia Of Esophagus

Congenital Imperforate Esophagus

Imperforate Esophagus

Oesophageal Atresia

Te Fistula

Tef

Tracheoesophageal Fistula With Or Without Esophageal Atresia
Vacterl Association, X-Linked, With Or Without Hydrocephalus

VACTERLX

X-Linked Vacterl Association

Vacterl-H, X-Linked

Vacterl Association, X-Linked

Vacterl Association, X-Linked With Or Without Hydrocephalus

Vacterl Association X-Linked With Or Without Hydrocephalus

Vacterl Syndrome

Vertebral Anal Tracheoesophageal Esophageal Radial Anomalies

X-Linked Vacterl-H

Vacterl Association

Vacterl Association With Hydrocephalus
Short-Rib Thoracic Dysplasia 10 With Or Without Polydactyly

SRTD10

Short-Rib Thoracic Dysplasia 10 Without Polydactyly

Short Rib-Polydactyly Syndrome
Tetralogy Of Fallot

TOF

Fallot Tetralogy

Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

Tetrad Of Fallot

Fallot Tetrad

Fallot Disease

Fallot Complex

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

Interventricular Septal Defect, In Tetralogy Of Fallot

Ventricular Septal Defect With Obstructed Right Ventricular Outflow

Tof - [Tetralogy Of Fallot]

Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

Pulmonary Atresia, Ventricular Septal Defect And Mapcas

Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Septic Arthritis

Infectious Arthritis

Arthritis, Infectious

Arthritis Septic

Arthritis, Bacterial
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07774 LPP Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus LPP MGD MGI:2441849
Rattus norvegicus LPP RGD RGD:1310535
Macaca fascicularis LPP NCBI
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