LYZ - lysozyme Gene

中文名称：溶菌酶

种属: Homo sapiens

同用名: LZM; LYZF1

基因 ID: 4069 | 基因类型: protein coding

关于 LYZ

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:69,348,381-69,354,234 (from NCBI)

This gene has 3 transcripts (splice variants), 407 orthologues, 8 paralogues and is associated with 2 phenotypes. Biased expression in stomach (RPKM 5710.8), salivary gland (RPKM 4398.2) and 8 other tissues.

功能概要

该基因编码人类溶菌酶，其天然底物是细菌细胞壁肽聚糖 (裂解 N-乙酰胞壁酸和 N-乙酰葡糖胺之间的 β[1-4] 糖苷键) 。溶菌酶是人乳中发现的一种抗菌剂，也存在于脾脏、肺、肾脏、白细胞、血浆、唾液和眼泪中。该蛋白质对多种细菌具有抗菌活性。已在遗传性肾淀粉样变性中鉴定出该基因的错义突变。[RefSeq 提供，2014 年 10 月]

This gene encodes human lysozyme, whose natural substrate is the Bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has Antibacterial activity against a number of Bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]

LYZ 基因产物(1)

mRNA	Protein	Name
NM_000239.3	NP_000230.1	lysozyme C precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	23353684	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in defense response to Gram-positive bacterium	IDA IDA: 通过直接分析推断	21093056	GOA
involved in defense response to bacterium	IDA IDA: 通过直接分析推断	21093056	GOA
involved in killing of cells of another organism	IDA IDA: 通过直接分析推断	9727055	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	21805676	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LYZ 蛋白结构

Lys

0
100
148 a.a.

蛋白主名

其他名称

lysozyme C

1,4-beta-N-acetylmuramidase C

LYZ 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	LYZ	P61626	IKBKB	Homo sapiens	O14920	TAP	14743216
种属内	LYZ	P61626	NFKBIB	Homo sapiens	Q15653	TAP	14743216
种属内	LYZ	P61626	CFP	Homo sapiens	P27918	ELISA	24355864
种属内	LYZ	P61626	LYZ	Homo sapiens	P61626	Light Scattering	23353684
种属内	LYZ	P61626	LYZ	Homo sapiens	P61626	EM	23353684
种属内	LYZ	P61626	gpmI	Bacillus anthracis	Q81X77	Y2H Pooling	20711500
种属内	LYZ	P61626	LYZ	Homo sapiens	P61626	Fluorescence	23353684

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LYZ 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70390	Lysozyme C/LYZ Protein, Human (HEK293, His)	P61626 (K19-V148)	≥95%

LYZ 抗体

目录号	产品名	应用	反应物种
HY-P80748	Lysozyme Antibody	WB, IHC-P	Human
HY-P85788	Lysozyme Antibody (YA5480)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P86037	Lysozyme Antibody (YA5729)	IHC-P, ELISA	Human, Mouse, Rat

关联疾病

疾病名称

别名

Amyloidosis, Familial Visceral

Ostertag Type Amyloidosis	German Type Amyloidosis
Familial Renal Amyloidosis	Amyloidosis Viii
Amyloidosis, 3 Or More Types	Familial Visceral Amyloidosis
Familial Amyloid Nephropathy	Hereditary Amyloid Nephropathy
Amyloidosis, Familial Renal	Amyloidosis, Systemic Nonneuropathic
Amyloidosis Familial Visceral	Amyloidosis 8
Amyloidosis, Ostertag Type	Hereditary Amyloidosis With Primary Renal Involvement
Hereditary Renal Amyloidosis	Renal Amyloidosis
Amyloidosis, Renal	Systemic Nonneuropathic Amyloidosis
Amyloidosis Familial Renal	Amyloidosis Systemic Nonneuropathic
Hereditary Amyloidosis With Primary Renal Involement	AMYL8
Systemic Non-Neuropathic Amyloidosis	Amyloid Nephropathy

Immunoglobulin Light Chain Amyloidosis

Al Amyloidosis	Primary Amyloidosis
Primary Systemic Amyloidosis	Light Chain Amyloidosis
Amyloidosis Al	Amyloidosis Primary Systemic
Primary Al Amyloidosis	Primary Systemic Al Amyloidosis
Systemic Al Amyloidsis	Systemic Al Amyloidosis
Light-Chain Amyloidosis	Alys Amyloidosis
Familial Amyloid Nephropathy Due To Lysozyme Variant	Familial Renal Amyloidosis Due To Lysozyme Variant
Hereditary Amyloid Nephropathy Due To Lysozyme Variant	Hereditary Renal Amyloidosis Due To Lysozyme Variant
Lysozyme Amyloidosis	Amyloidosis Primary
Immunoglobulin Deposition Disease	Immunoglobulinic Amyloidosis
Amyloid Al

Amyloidosis

Amyloid Disease	Amyloid
Amyloid Degeneration	Amyloidosis Nos
Amyloid Deposition	Amyloid Infiltration
Idiopathic Amyloidosis	Hyaloid Degeneration
Lardaceous Degeneration

Tuberculous Meningitis

Tubercular Meningitis	Tb Meningitis
Tuberculosis, Meningeal	Tbm
Meningitis Tuberculous	Tbm - [Tuberculous Meningitis]
Meningitis Due To Mycobacterium Tb	Caseous Meningitis
Tuberculous Meninges Adhesions	Tuberculous Leptomeningitis
Meningeal Tuberculosis	Meningeal Tb
Meningeal Tbc - [Tuberculosis]

Malignant Adenofibroma

Adenocarcinofibroma

Meningitis

Streptococcal Meningitis	Acute Streptococcal Meningitis
Staphylococcal Meningitis	Adenoviral Meningitis
Influenza Meningitis	Influenzal Meningitis
Meningitis Due To H. Influenzae	Cryptococcal Meningitis
Fungal Meningitis Due To Cryptococcus Neoformans	Cryptococcosis Meningitis
Cryptococcus Meningitis	Cryptococcal Meningoencephalitis
Meningitis Due To Cryptococcus	Mumps Virus Meningitis
Mumps Meningitis

Isthmus Cancer

Hereditary Amyloidosis

Amyloidosis Hereditary	Familial Amyloidosis
Amyloidosis Familial	Amyloidosis, Hereditary
Amyloidosis, Familial	Genetic Amyloidosis
Heredofamilial Amyloidosis

Opportunistic Bacterial Infectious Disease

Nocardiosis

Nocardia Infection	Nocardia Infections
Nocardia Infectious Disease	Lung Nocardiosis
Nocardiasis	Nocardiosis Nos

Bacterial Meningitis

Meningitis, Bacterial	Meningitis Bacterial
Bm - [Bacterial Meningitis]	Leptomeningitis Bacterial
Pachymeningitis Bacterial	Arachnoiditis Bacterial

Dental Caries

Dental Caries Extending Into Pulp	Dental Caries Of Smooth Surface
Dental Caries Pit And Fissure	Smooth Surface Dental Caries
Dental Decay	Carious Teeth
Dental Cavity	Saprodontia
Teeth Decayed	Tooth Caries
Tooth Decay

Anaerobic Pneumonia

Pneumonia Due To Anaerobes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07930	LYZ Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-W109513	Boc-Lys(Z)-OH (DCHA)		/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	LYZ	VGNC	VGNC:74466
Canis familiaris	LYZ	VGNC	VGNC:42901
Rattus norvegicus	LYZ	RGD	RGD:3026
Felis catus	LYZ	VGNC	VGNC:68114
Others	LYZ	NCBI

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站点地图隐私声明

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LYZ - lysozyme Gene

关于 LYZ

功能概要

LYZ 基因产物(1)

LYZ 蛋白结构

LYZ 蛋白互作信息

重组 LYZ 蛋白

LYZ 抗体

关联疾病

直系同源

热门区域

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LYZ - lysozyme Gene

关于 LYZ

功能概要

LYZ 基因产物(1)

LYZ 蛋白结构

LYZ 蛋白互作信息

重组 LYZ 蛋白

LYZ 抗体

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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