DEFB103A - defensin beta 103A Gene

中文名称：防御素β 103A

种属: Homo sapiens

同用名: BD-3; HBD3; HBP3; DEFB3; HBP-3; DEFB-3; DEFB103

基因 ID: 414325 | 基因类型: protein coding

关于 DEFB103A

This gene has 1 transcript (splice variant), 1 gene allele, 94 orthologues and 1 paralogue. Low expression observed in reference dataset.

功能概要

防御素形成一个由中性粒细胞产生的杀微生物和细胞毒性肽家族。防御素家族的成员在蛋白质序列上高度相似。该基因编码防御素，β 103，一种由细菌和干扰素 γ 诱导的抗生素肽，显示出对金黄色葡萄球菌、化脓性链球菌、铜绿假单胞菌、大肠杆菌和白色念珠菌的抗菌活性。[RefSeq 提供，2014 年 10 月]

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103, an Antibiotic peptide which is induced by bacteria and interferon gamma, and which displays antimicrobial activity against S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. [provided by RefSeq, Oct 2014]

DEFB103A 基因产物(1)

mRNA	Protein	Name
NM_001081551.4	NP_001075020.1	beta-defensin 103 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: 通过直接分析推断	11085990	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: 通过直接分析推断	11085990	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: 通过直接分析推断	15625724	GOA
involved in defense response to Gram-positive bacterium	IEP IEP: 通过表达模式推断	11085990	GOA
acts upstream of or within defense response to bacterium	IMP IMP: 通过突变表型推断	21115716	GOA
involved in killing by host of symbiont cells	IDA IDA: 通过直接分析推断	16436752	GOA
involved in killing of cells of another organism	IDA IDA: 通过直接分析推断	11085990	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	21115716	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DEFB103A 蛋白结构

Defensin_beta

0
67 a.a.

蛋白主名

其他名称

beta-defensin 103

beta-defensin 3

DEFB103A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DEFB103A	P81534	SPATA31A7	Homo sapiens	Q8IWB4	Validated Y2H	32296183
种属内	DEFB103A	P81534	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
种属内	DEFB103A	P81534	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
种属内	DEFB103A	P81534	ODF4	Homo sapiens	Q2M2E3	Y2H Prey Pooling	32296183
种属内	DEFB103A	P81534	ODF4	Homo sapiens	Q2M2E3	Validated Y2H	32296183
种属内	DEFB103A	P81534	ODF4	Homo sapiens	Q2M2E3	Y2H Array	32296183
种属内	DEFB103A	P81534	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
种属内	DEFB103A	P81534	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
种属内	DEFB103A	P81534	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
种属内	DEFB103A	P81534	B3GALT5	Homo sapiens	Q9Y2C3	Validated Y2H	32296183
种属内	DEFB103A	P81534	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
种属内	DEFB103A	P81534	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
种属内	DEFB103A	P81534	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
种属内	DEFB103A	P81534	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
种属内	DEFB103A	P81534	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
种属内	DEFB103A	P81534	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
种属内	DEFB103A	P81534	EBP	Homo sapiens	Q15125	Y2H Array	32296183
种属内	DEFB103A	P81534	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
种属内	DEFB103A	P81534	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
种属内	DEFB103A	P81534	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
种属内	DEFB103A	P81534	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
种属内	DEFB103A	P81534	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
种属内	DEFB103A	P81534	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
种属内	DEFB103A	P81534	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
种属内	DEFB103A	P81534	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 DEFB103A 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7137	BD-3 Protein, Human	P81534 (G23-K67)	≥95%

关联疾病

疾病名称

别名

Ileitis

Crohn'S Ileitis

Cardiomyopathy, Familial Hypertrophic, 12

Hypertrophic Cardiomyopathy 12	CMH12
Cardiomyopathy, Hypertrophic, 12	Cardiomyopathy Familial Hypertrophic 12
Cardiomyopathy, Familial Hypertrophic 12	Cardiomyopathy, Hypertrophic, Familial, Type 12

Cardiomyopathy, Familial Hypertrophic, 6

Hypertrophic Cardiomyopathy 6	CMH6
Familial Hypertrophic Cardiomyopathy With Wolff-Parkinson-White Syndrome	Cardiomyopathy, Familial Hypertrophic 6
Cardiomyopathy, Hypertrophic 6	Cardiomyopathy, Hypertrophic, Familial, Type 6

Eczema Herpeticum

Herpes Simplex Dermatitis	Herpes Simplex Eyelid Dermatitis
Kaposi Varicelliform Eruption	Herpes Simplex Dermatitis Of Eyelid
Herpes Simplex Virus Dermatitis	Herpes Simplex Virus Eyelid Dermatitis

Denture Stomatitis

Stomatitis, Denture

Denture Sore Mouth

Crohn'S Colitis

Crohn Disease

Oral Candidiasis

Thrush	Candidiasis Of Mouth
Oral Moniliasis	Thrush, Oral
Candidiasis, Oral	Oral Thrush
Candidiasis	Equine Thrush

Vaginal Disease

Vaginal Diseases

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03679	DEFB103A Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	DEFB103A	MGD	MGI:2675345
Rattus norvegicus	DEFB103A	RGD	RGD:1561378

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DEFB103A - defensin beta 103A Gene

关于 DEFB103A

功能概要

DEFB103A 基因产物(1)

DEFB103A 蛋白结构

DEFB103A 蛋白互作信息

重组 DEFB103A 蛋白

关联疾病

直系同源

热门区域

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DEFB103A - defensin beta 103A Gene

关于 DEFB103A

功能概要

DEFB103A 基因产物(1)

DEFB103A 蛋白结构

DEFB103A 蛋白互作信息

重组 DEFB103A 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z