2. Gene
  3. MVD - mevalonate diphosphate decarboxylase Gene

MVD - mevalonate diphosphate decarboxylase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：甲羟戊酸二磷酸脱羧酶

种属: Homo sapiens

同用名: MPD; MDDase; POROK7; FP17780

基因 ID: 4597 | 基因类型: protein coding

关于 MVD

Cytogenetic location: 16q24.2 Genomic coordinates (GRCh38): 16:88,651,940-88,663,091 (from NCBI)

This gene has 17 transcripts (splice variants), 199 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 12.6), duodenum (RPKM 12.3) and 25 other tissues.

功能概要

在胆固醇生物合成的早期步骤之一中，酶甲羟戊酸焦磷酸脱羧酶催化甲羟戊酸焦磷酸转化为异戊烯基焦磷酸。它在水解 ATP 的同时使其底物脱羧和脱水。[RefSeq 提供，2008 年 7 月]

The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in Cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]

MVD 基因产物(1)

mRNA Protein Name
NM_002461.3 NP_002452.1 diphosphomevalonate decarboxylase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Hsp70 protein binding IPI
IPI: 通过物理相互作用推断
12646231 GOA
enables diphosphomevalonate decarboxylase activity IDA
IDA: 通过直接分析推断
11792727 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
8626466 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in isoprenoid biosynthetic process IDA
IDA: 通过直接分析推断
11792727 GOA
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
9270019 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
14972328 GOA
NOT located in peroxisome IDA
IDA: 通过直接分析推断
14972328 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MVD 蛋白结构

GHMP_kinases_N

GHMP_kinases_N: GHMP kinases N terminal domain (112 - 156)

  • 0
  • 100
  • 200
  • 300
  • 400 a.a.
蛋白主名 其他名称

diphosphomevalonate decarboxylase

mevalonate (diphospho) decarboxylase

关联疾病

疾病名称 别名
Porokeratosis 7, Multiple Types

POROK7

Porokeratosis 7, Disseminated Superficial Actinic Type
Porokeratosis

Disseminated Superficial Actinic Porokeratosis

Dsap

Porokeratosis Of Mibelli

Porokeratosis, Disseminated Superficial Actinic

Porokeratosis, Disseminated Superficial Actinic, 1
Linear Porokeratosis

Congenital Facial Linear Porokeratosis

Porokeratosis, Linear
Scirrhous Adenocarcinoma

Adenocarcinoma, Scirrhous

Adenocarcinoma With Productive Fibrosis
Punctate Porokeratosis

Porokeratosis, Punctate

Keratoderma, Palmoplantar, Punctate Type Ii
Ck Syndrome

CKS

X-Linked Intellectual Disability-Microcephaly-Cortical Malformation-Thin Habitus Syndrome

Mental Retardation, X-Linked, With Thin Body Habitus And Cortical Malformation
Zellweger Syndrome

Cerebrohepatorenal Syndrome

Zellweger Leukodystrophy

Zs

Congenital Iron Overload

Chr

Zws

Severe Pbd-Zsd

Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13561 AZM475271 99.89% 否
HY-P1596 Gluten Exorphin C Inhibitor 99.86% 否
HY-P3632 [DAla2, DArg6] Dynorphin A, (1-13) (porcine) / 否
HY-RS08856 MVD Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18453 Mvd Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24934 Mvd Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus MVD VGNC VGNC:31767
Canis familiaris MVD VGNC VGNC:43508
Felis catus MVD VGNC VGNC:68364
Rattus norvegicus MVD RGD RGD:621292
Mus musculus MVD MGD MGI:2179327
Macaca mulatta MVD VGNC VGNC:82192
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