MYL4 - myosin light chain 4 Gene

中文名称：肌球蛋白轻链 4

种属: Homo sapiens

同用名: GT1; ALC1; AMLC; PRO1957

基因 ID: 4635 | 基因类型: protein coding

关于 MYL4

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,189,433-47,227,650 (from NCBI)

This gene has 10 transcripts (splice variants), 290 orthologues, 4 paralogues and is associated with 2 phenotypes. Restricted expression toward heart (RPKM 587.0).

功能概要

肌球蛋白是一种六聚体 ATP 酶细胞运动蛋白。它由两条肌球蛋白重链、两条不可磷酸化的肌球蛋白碱金属轻链和两条可磷酸化的肌球蛋白调节轻链组成。该基因编码在胚胎肌肉和成人心房中发现的肌球蛋白碱性轻链。已经为该基因发现了编码相同蛋白质的两个选择性剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

Myosin is a hexameric ATPase cellular motor protein. It is composed of two Myosin heavy chains, two nonphosphorylatable Myosin alkali light chains, and two phosphorylatable Myosin regulatory light chains. This gene encodes a Myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

MYL4 基因产物(2)

mRNA	Protein	Name
NM_001002841.2	NP_001002841.1	myosin light chain 4
NM_002476.2	NP_002467.1	myosin light chain 4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables actin filament binding	IMP IMP: 通过突变表型推断	9738905	GOA
enables actin monomer binding	IDA IDA: 通过直接分析推断	9180271	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cardiac muscle contraction	IMP IMP: 通过突变表型推断	14985854	GOA
involved in positive regulation of ATP-dependent activity	IMP IMP: 通过突变表型推断	9738905	GOA
involved in regulation of the force of heart contraction	IMP IMP: 通过突变表型推断	16675844	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in A band	IMP IMP: 通过突变表型推断	14985854	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MYL4 蛋白结构

EF-hand_6

0
100
197 a.a.

蛋白主名

其他名称

myosin light chain 4

atrial myosin light chain 1

MYL4 抗体

目录号	产品名	应用	反应物种
HY-P85656	Myosin Heavy Chain Antibody (YA5348)	ICC/IF	Human, Mouse, Rat, FruitFly, Nematode

关联疾病

疾病名称

别名

Atrial Fibrillation, Familial, 18

ATFB18

Fibrillation, Atrial, Familial, Type 18

Familial Atrial Fibrillation

Atrial Fibrillation, Familial	Atfb
Atrial Fibrillation Autosomal Dominant	Autosomal Dominant Atrial Fibrillation
Auricular Fibrillation	Atrial Fibrillation
Atrial Fibrillation, Familial, 1

Atrial Fibrillation

A-Fib	Fibrillation, Atrial
Af - [Atrial Fibrillation]	Rapid Atrial Fibrillation
A Fib - [Atrial Fibrillation]

Aortic Valve Disease 2

Aortic Valve Stenosis	Aortic Stenosis
Rheumatic Aortic Stenosis	AOVD2
Bicuspid Aortic Valve	Rheumatic Aortic Valve Stenosis
Valvular Aortic Stenosis	Aortic Valve Disease, Type 2
Aortic Valve Stricture	Aortic Valve Obstruction
Obstructed Aorta Valve	Rheumatic Aortic Obstruction
Rheumatic Aortic Valve Obstruction	Rheumatic Aortic Stricture
Aortic Valve Regurgitation	Aortic Insufficiency With Stenosis
Rheumatic Aortic Valve Stenosis With Insufficiency	Rheumatic Aortic Stenosis With Incompetence
Rheumatic Aortic Stenosis With Regurgitation

Acute Myocardial Infarction

Cardiac Attack

Heart Attack

Pleomorphic Rhabdomyosarcoma

Adult Pleomorphic Rhabdomyosarcoma	Anaplastic Rhabdomyosarcoma
Pleomorphic Rhabdomyosarcoma, Adult Type

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Congenital Fiber-Type Disproportion

Congenital Fiber Type Disproportion	Cftdm
Congenital Myopathy With Fiber Type Disproportion	Cftd
Congenital Fiber-Type Disproportion Myopathy	Fiber-Type Disproportion Myopathy, Congenital
Myopathy, Congenital With Fiber-Type Disproportion

Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy	Familial Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 1	CMH1
Hypertrophic Cardiomyopathy 19	CMH
Ventricular Hypertrophy, Hereditary	Ash
Hypertrophic Subaortic Stenosis, Idiopathic	Cardiomyopathy, Familial Hypertrophic
Cardiomyopathy, Hypertrophic, 1, Digenic	Cardiomyopathy, Familial Hypertrophic 1
Hcm	Hereditary Ventricular Hypertrophy
Idiopathic Hypertrophic Subaortic Stenosis	Hypertrophic Cardiomyopathy
Cardiomyopathy, Hypertrophic, Familial	Cardiomyopathy, Hypertrophic, 1
Familial Asymmetric Septal Hypertrophy	Heritable Hypertrophic Cardiomyopathy
Fhc	Cardiomyopathy, Hypertrophic, Familial, Type 1

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08916	MYL4 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS21385	Myl4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS27904	Myl4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	MYL4	RGD	RGD:1591197
Canis familiaris	MYL4	VGNC	VGNC:55648
Mus musculus	MYL4	MGD	MGI:97267
Felis catus	MYL4	VGNC	VGNC:68384
Bos taurus	MYL4	VGNC	VGNC:31802
Macaca mulatta	MYL4	VGNC	VGNC:75105

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MYL4 - myosin light chain 4 Gene

关于 MYL4

功能概要

MYL4 基因产物(2)

MYL4 蛋白结构

MYL4 抗体

关联疾病

直系同源

热门区域

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MYL4 - myosin light chain 4 Gene

关于 MYL4

功能概要

MYL4 基因产物(2)

MYL4 蛋白结构

MYL4 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z