MYO9B - myosin IXB Gene

中文名称：肌球蛋白 IXB

种属: Homo sapiens

同用名: MYR5; CELIAC4

基因 ID: 4650 | 基因类型: protein coding

关于 MYO9B

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,075,777-17,215,255 (from NCBI)

This gene has 20 transcripts (splice variants), 282 orthologues, 43 paralogues and is associated with 1 phenotype. Broad expression in spleen (RPKM 30.6), bone marrow (RPKM 21.4) and 24 other tissues.

功能概要

该基因编码基于肌动蛋白的分子马达重链蛋白的肌球蛋白家族成员。该蛋白质代表一种非常规的肌球蛋白；它不应与传统的非肌肉肌球蛋白 9 (MYH9) 混淆。该蛋白质有四个 IQ 基序，位于结合钙调蛋白的颈部区域，钙调蛋白用作轻链。蛋白质复合物具有单头结构，并在肌动蛋白丝上向负端显示进行性运动。该蛋白质还具有 rho-GTP 酶活性。该基因的多态性与乳糜泻和溃疡性结肠炎的易感性有关。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 12 月]

This gene encodes a member of the Myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind Calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

MYO9B 基因产物(2)

mRNA	Protein	Name
NM_001130065.2	NP_001123537.1	unconventional myosin-IXb isoform 2
NM_004145.4	NP_004136.2	unconventional myosin-IXb isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ADP binding	IDA IDA: 通过直接分析推断	16338935	GOA
enables ATP binding	IDA IDA: 通过直接分析推断	16338935	GOA
enables GTPase activator activity	IDA IDA: 通过直接分析推断	9490638	GOA
enables Roundabout binding	IPI IPI: 通过物理相互作用推断	26529257	GOA
enables actin binding	IDA IDA: 通过直接分析推断	9490638	GOA
enables calmodulin binding	IDA IDA: 通过直接分析推断	9490638	GOA
enables microfilament motor activity	IDA IDA: 通过直接分析推断	9490638	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15644318	GOA
NOT enables protein homodimerization activity	IDA IDA: 通过直接分析推断	11901422	GOA
enables small GTPase binding	IPI IPI: 通过物理相互作用推断	26529257	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
NOT involved in ARF protein signal transduction	IDA IDA: 通过直接分析推断	15644318	GOA
involved in Roundabout signaling pathway	IDA IDA: 通过直接分析推断	26529257	GOA
involved in actin filament-based movement	IDA IDA: 通过直接分析推断	9490638	GOA
involved in regulation of Rho protein signal transduction	IMP IMP: 通过突变表型推断	26529257	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in actin filament	IDA IDA: 通过直接分析推断	8907710	GOA
located in cell cortex	IDA IDA: 通过直接分析推断	8907710	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	8907710	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	8907710	GOA
is active in postsynaptic actin cytoskeleton	IDA IDA: 通过直接分析推断	30123108	GOA
is active in postsynaptic actin cytoskeleton	IMP IMP: 通过突变表型推断	30123108	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MYO9B 蛋白结构

Myosin_head

RhoGAP

0
400
800
1200
1600
2000
2157 a.a.

蛋白主名

其他名称

unconventional myosin-IXb

myosin-IXb

关联疾病

疾病名称

别名

Celiac Disease 4

Celiac Disease, Susceptibility To, 4	CELIAC4
Gluten-Sensitive Enteropathy 4	Gluten-Sensitive Enteropathy, Susceptibility To, 4
Celiac Disease, Susceptibility To, Type 4

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Dermatitis Herpetiformis

Duhring'S Disease	Duhring-Brocq Disease
Dermatosis Herpetiformis	Brocq-Duhring Disease
Dh	Duhring Brocq Disease
Dh - [Dermatitis Herpetiformis]

Ulcerative Colitis

Colitis Gravis	Left Sided Ulcerative Colitis
Left-Sided Ulcerative Colitis	Idiopathic Proctocolitis
Inflammatory Bowel Disease, Ulcerative Colitis Type	Uc
Colitis Ulcerative	Colitis, Ulcerative
Chronic Left-Sided Ulcerative Colitis	Uc - [Ulcerative Colitis]
Chronic Ulcerative Enteritis	Mucosal Proctocolitis
Ulcerative Mucosal Proctocolitis	Left Hemicolitis

Inflammatory Bowel Disease 6

IBD6

Colitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Jejunoileitis

Inflammatory Bowel Disease 5

IBD5

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08953	MYO9B Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS22665	Myo9b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS29179	Myo9b Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	MYO9B	RGD	RGD:3146
Canis familiaris	MYO9B	VGNC	VGNC:43575
Felis catus	MYO9B	VGNC	VGNC:68402
Bos taurus	MYO9B	VGNC	VGNC:31832
Mus musculus	MYO9B	MGD	MGI:106624

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MYO9B - myosin IXB Gene

关于 MYO9B

功能概要

MYO9B 基因产物(2)

MYO9B 蛋白结构

关联疾病

直系同源

热门区域

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MYO9B - myosin IXB Gene

关于 MYO9B

功能概要

MYO9B 基因产物(2)

MYO9B 蛋白结构

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z