NBL1 - NBL1, DAN family BMP antagonist Gene

中文名称：NBL1，DAN 家族 BMP 拮抗因子

种属: Homo sapiens

同用名: NB; DAN; NO3; DAND1; D1S1733E

关于 NBL1

功能概要

该基因产物是进化上保守的 CAN (Cerberus 和 DAN) 蛋白质家族的创始成员，该家族包含一个类似于在许多信号分子中发现的 CTCK (C 末端胱氨酸结样) 基序的结构域。这些蛋白质被分泌出来，并通过与 BMP 结合并阻止它们与其受体相互作用而充当 BMP (骨形态发生蛋白) 拮抗剂。因此，它们可能在生长发育过程中发挥重要作用。已经确定了该基因的可变剪接转录物变体。已观察到该基因座与上游线粒体内膜组织系统 1 基因 (GeneID 440574) 之间的通读转录本。[RefSeq 提供，2013 年 5 月]

This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]