2. Gene
  3. NDUFB4 - NADH:ubiquinone oxidoreductase subunit B4 Gene

NDUFB4 - NADH:ubiquinone oxidoreductase subunit B4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NADH：泛醌氧化还原酶 B4 亚基

种属: Homo sapiens

同用名: B15; CI-B15

基因 ID: 4710 | 基因类型: protein coding

关于 NDUFB4

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:120,596,336-120,602,507 (from NCBI)

This gene has 6 transcripts (splice variants) and 227 orthologues. Ubiquitous expression in adrenal (RPKM 52.4), heart (RPKM 52.2) and 25 other tissues.

功能概要

该基因编码多亚基 NADH 的非催化亚基：泛醌氧化还原酶，线粒体电子传递链中的第一个酶复合物 (复合物 I) 。哺乳动物复合物 I 由 45 个不同的亚基组成，并将电子从 NADH 转移到泛醌。[RefSeq 提供，2009 年 12 月]

This gene encodes a non-catalytic subunit of the multisubunit NADH:ubiquinone oxidoreductase, the first enzyme complex in the mitochondrial electron transport chain (complex I). Mammalian complex I is composed of 45 different subunits and transfers electrons from NADH to ubiquinone. [provided by RefSeq, Dec 2009]

NDUFB4 基因产物(2)

mRNA Protein Name
NM_001168331.2 NP_001161803.1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 isoform 2
NM_004547.6 NP_004538.2 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 isoform 1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mitochondrial respiratory chain complex I assembly IMP
IMP: 通过突变表型推断
27626371 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
28844695 GOA
part of respiratory chain complex I IDA
IDA: 通过直接分析推断
12611891 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NDUFB4 蛋白结构

NDUF_B4

NDUF_B4: NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) (5 - 129)

  • 0
  • 100
  • 129 a.a.
蛋白主名 其他名称

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa

NDUFB4 抗体

目录号 产品名 应用 反应物种
HY-P81593 NDUFB4 Antibody (YA1338) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Polyomavirus-Associated Nephropathy

Polyomavirus Associated Nephropathy

Pvan
Latex Allergy
Hantavirus Hemorrhagic Fever With Renal Syndrome

Hemorrhagic Fever, Russian

Hemorrhagic Nephrosonephritis

Hfrs

Puumala Virus Nephropathy

Hemorrhagic Fever With Renal Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09149 NDUFB4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21894 Ndufb4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28411 Ndufb4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NDUFB4 RGD RGD:1307072
Felis catus NDUFB4 VGNC VGNC:102785
Canis familiaris NDUFB4 VGNC VGNC:43703
Mus musculus NDUFB4 MGD MGI:1915444
Macaca mulatta NDUFB4 VGNC VGNC:75157
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