1. Gene
  2. NEO1 - neogenin 1 Gene

NEO1 - neogenin 1 Gene

中文名称:新生素 1

种属: Homo sapiens

同用名: NGN; IGDCC2; NTN1R2

基因 ID: 4756 | 基因类型: protein coding

关于 NEO1

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:73,051,692-73,305,206 (from NCBI)

This gene has 11 transcripts (splice variants), 244 orthologues and 36 paralogues. Broad expression in colon (RPKM 23.2), skin (RPKM 16.0) and 23 other tissues.

功能概要

该基因编码的细胞表面蛋白是免疫球蛋白超家族的一员。编码的蛋白质由四个 N 端免疫球蛋白样结构域、六个纤连蛋白 III 型结构域、一个跨膜结构域和一个与肿瘤抑制候选基因 DCC 具有同源性的 C 端内部结构域组成。这种蛋白质可能参与细胞生长和分化以及细胞间粘附。该基因的缺陷与某些癌症的细胞增殖有关。交替剪接导致多个转录本变体。[RefSeq 提供,2010 年 2 月]

This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

NEO1 基因产物(3)

mRNA Protein Name
NM_001172623.1 NP_001166094.1 neogenin isoform 2 precursor
NM_001172624.1 NP_001166095.1 neogenin isoform 3 precursor
NM_002499.4 NP_002490.2 neogenin isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables co-receptor binding IPI
IPI: 通过物理相互作用推断
18335997 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18335997 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within multicellular organismal-level iron ion homeostasis IGI
IGI: 通过遗传相互作用推断
16075058 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of plasma membrane protein complex IDA
IDA: 通过直接分析推断
18335997 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NEO1 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (65 - 147)

I-set

I-set: Immunoglobulin I-set domain (152 - 239)

I-set

I-set: Immunoglobulin I-set domain (250 - 337)

I-set

I-set: Immunoglobulin I-set domain (341 - 427)

fn3

fn3: Fibronectin type III domain (440 - 525)

fn3

fn3: Fibronectin type III domain (543 - 618)

fn3

fn3: Fibronectin type III domain (636 - 720)

fn3

fn3: Fibronectin type III domain (742 - 818)

fn3

fn3: Fibronectin type III domain (856 - 942)

fn3

fn3: Fibronectin type III domain (956 - 1044)

Neogenin_C

Neogenin_C: Neogenin C-terminus (1156 - 1461)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1461 a.a.
蛋白主名 其他名称

neogenin

immunoglobulin superfamily DCC subclass member 2

重组 NEO1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P701081 Neogenin Protein, Human (HEK293, hFc) Q92859-1 (A34-L1105) ≥95%

关联疾病

疾病名称 别名
Corneal Intraepithelial Neoplasm
Hemochromatosis Type 2

Juvenile Hemochromatosis

Juvenile Hereditary Hemochromatosis

Hfe2

Jhh

Hemochromatosis Juvenile

Iron Overload Disease Juvenile

Hemochromatosis, Juvenile

Hemochromatosis, Type 2

Hemochromatosis

Hemochromatosis, Type 1

Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma

DMSMFH

Bone Dysplasia With Medullary Fibrosarcoma

Bdmf

Bone Dysplasia With Malignant Fibrous Histiocytoma

Hardcastle Syndrome

Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome

Myopathy, Limb-Girdle, With Bone Fragility

Bone Dysplasia-Medullary Fibrosarcoma Syndrome

Diaphyseal Medullary Stenosis-Malignant Fibrous Histiocytoma Syndrome

Dms-Mfh

Limb-Girdle Myopathy With Bone Fragility

Stenosis, Medullary, Diaphyseal, With Malignant Fibrous Histiocytoma

Hemochromatosis, Type 1

Hemochromatosis

Hemochromatosis Type 1

Hereditary Hemochromatosis

Hh

HFE1

Hfe Hemochromatosis, Modifier Of

Symptomatic Form Of Classic Hemochromatosis

Symptomatic Form Of Hemochromatosis Type 1

Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

Haemochromatosis

Iron Storage Disorder

Bronze Diabetes

Hereditary Haemochromatosis

Hlah

Hfe

Hemochromatosis, Hereditary

Diabetes Bronze

Classic Hemochromatosis

Hfe-Associated Hereditary Hemochromatosis

Hemochromatosis Classic

Bronzed Cirrhosis

Familial Hemochromatosis

Genetic Hemochromatosis

Hc

Pigmentary Cirrhosis

Primary Hemochromatosis

Troisier-Hanot-Chauffard Syndrome

Von Recklenhausen-Applebaum Disease

Hemochromatosis 1

Primary Hereditary Hemochromatosis

Bronze Cirrhosis

Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1

Dysequilibrium Syndrome

CAMRQ1

Des

Cerebellar Ataxia, Intellectual Disability, And Dysequilibrium Syndrome 1

Cerebellar Hypoplasia, Vldlr-Associated

Cerebellar Hypoplasia And Mental Retardation With Or Without Quadrupedal Locomotion 1

Cerebellar Ataxia, Mental Retardation And Dysequlibrium Syndrome

Uner Tan Syndrome

Vldlr Cerebellar Hypoplasia

Vldlrch

Vldlr-Associated Cerebellar Hypoplasia

Cerebellar Ataxia And Mental Retardation With Or Without Quadrupedal Locomotion 1

Cerebellar Ataxia, Congenital, And Mental Retardation, Autosomal Recessive

Camrq

Cerebellar Ataxia, Mental Retardation, Dysequilibrium Syndrome 1

Cerebellar Disorder, Nonprogressive, With Intellectual Disability

Cerebellar Hypoplasia, Vldlr Associated

Autosomal Recessive Cerebellar Ataxia With Mental Retardation

Autosomal Recessive Cerebellar Hypoplasia With Cerebral Gyral Simplification

Cerebellar Disorder, Nonprogressive, With Mental Retardation

Cerebellar Hypoplasia And Mental Retardation With Or Without Quadrupedal Locomotion

Chmrq1

Des-Vldlr

Dysequilibrium Syndrome-Vldlr

Vldlr-Ch

Camrq Syndrome

Cerebellar Ataxia-Intellectual Disability-Dysequilibrium Syndrome Syndrome

Non-Progressive Cerebellar Ataxia-Intellectual Disability Syndrome

Uts

Cerebellar Hypoplasia Vldlr-Associated

Dialysis Disequilibrium Syndrome

Deficiency Anemia

Anemia

Deficiency Anemias

Anaemia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus NEO1 VGNC VGNC:32007
Rattus norvegicus NEO1 RGD RGD:619837
Felis catus NEO1 VGNC VGNC:80901
Macaca mulatta NEO1 VGNC VGNC:75314
Mus musculus NEO1 MGD MGI:1097159
Canis familiaris NEO1 VGNC VGNC:43745
Others NEO1 NCBI