2. Gene
  3. NPAT - nuclear protein, coactivator of histone transcription Gene

NPAT - nuclear protein, coactivator of histone transcription Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核蛋白，组蛋白转录的共激活因子

种属: Homo sapiens

同用名: E14; p220; E14/NPAT

基因 ID: 4863 | 基因类型: protein coding

关于 NPAT

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:108,157,215-108,222,638 (from NCBI)

This gene has 6 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in lymph node (RPKM 6.0), spleen (RPKM 3.9) and 25 other tissues.

功能概要

启用蛋白质 C 末端结合活性；转录共激活因子活性；和转录辅阻遏物活性。参与 RNA 聚合酶 II 的转录正调控和参与有丝分裂细胞周期 G1/S 转换的转录调控。位于 Cajal 体内；盘绕体的双子座；和细胞质。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein C-terminus binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in positive regulation of transcription by RNA polymerase II and regulation of transcription involved in G1/S transition of mitotic cell cycle. Located in Cajal body; Gemini of coiled bodies; and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NPAT 基因产物(2)

mRNA Protein Name
NM_001321307.1 NP_001308236.1 protein NPAT isoform 1
NM_002519.3 NP_002510.2 protein NPAT isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15988025 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
14585971 GOA
enables transcription coactivator activity IMP
IMP: 通过突变表型推断
15988025 GOA
enables transcription corepressor activity IMP
IMP: 通过突变表型推断
17163457 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell cycle G1/S phase transition IMP
IMP: 通过突变表型推断
15988025 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
18850719 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
18850719 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
15988025 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Cajal body IDA
IDA: 通过直接分析推断
15988025 GOA
located in Gemini of coiled bodies IDA
IDA: 通过直接分析推断
17068332 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
17068332 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
17068332 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15988025 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein NPAT

nuclear protein of the ATM locus

关联疾病

疾病名称 别名
Ataxia-Telangiectasia

Ataxia Telangiectasia

Louis-Bar Syndrome

AT

At1

Ataxia-Telangiectasia Syndrome

Ataxia - Telangiectasia Variant

Boder-Sedgwick Syndrome

Louis Bar Syndrome

Cerebello-Oculocutaneous Telangiectasia

Immunodeficiency With Ataxia Telangiectasia

A-T

Ataxia Telangiectasia Syndrome

Atm

Telangiectasia, Cerebello-Oculocutaneous

Ataxia-Telangiectasia Variant
Nasal Cavity Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Nasal Cavity

Squamous Cell Carcinoma Of The Nasal Cavity
Alpha Thalassemia-Intellectual Disability Syndrome Type 1

Alpha Thalassemia-Intellectual Disability Syndrome, Deletion Type

Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16

Atr Syndrome Linked To Chromosome 16

Atr Syndrome, Deletion Type

Atr-16 Syndrome

Alpha Thalassemia-Retardation Syndrome

Alpha-Thalassemia/Mental Retardation Syndrome, Deletion-Type

Alpha-Thalassemia/Mental Retardation Syndrome, Type 1

Alpha-Thalassemia Mental Retardation Syndrome, Deletion-Type
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09472 NPAT Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NPAT VGNC VGNC:50638
Mus musculus NPAT MGD MGI:107605
Felis catus NPAT VGNC VGNC:68527
Bos taurus NPAT VGNC VGNC:50617
Rattus norvegicus NPAT RGD RGD:1311947
Macaca mulatta NPAT VGNC VGNC:75379
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