2. Gene
  3. NPR1 - natriuretic peptide receptor 1 Gene

NPR1 - natriuretic peptide receptor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：利钠肽受体 1

种属: Homo sapiens

同用名: ANPa; NPRA; ANPRA; GUC2A; GUCY2A

基因 ID: 4881 | 基因类型: protein coding

关于 NPR1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,678,688-153,693,992 (from NCBI)

This gene has 3 transcripts (splice variants), 185 orthologues and 17 paralogues. Biased expression in fat (RPKM 49.0), lung (RPKM 10.4) and 9 other tissues.

功能概要

催化 GTP 产生 cGMP 的鸟苷酸环化酶分为可溶性和膜形式 (Garbers 和 Lowe，1994 [PubMed 7982997]) 。膜鸟苷酸环化酶，通常称为鸟苷酸环化酶 A 到 F，形成具有相似拓扑结构的细胞表面受体家族：一个细胞外配体结合域、一个跨膜域和一个包含蛋白激酶的细胞内区域-样结构域和环化酶催化结构域。 GC-A 和 GC-B 作为利尿钠肽的受体发挥作用；它们也被称为心钠素受体 A (NPR1) 和 B 型 (NPR2; MIM 108961) 。另见 NPR3 (MIM 108962) ，它编码的蛋白质只有配体结合跨膜结构域和 37 个氨基酸的胞质结构域。 NPR1 是一种膜结合的鸟苷酸环化酶，可作为心房和脑利钠肽 (分别为 ANP (MIM 108780) 和 BNP (MIM 600295) ) 的受体。[OMIM 提供，2009 年 5 月]

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound Guanylate Cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]

NPR1 基因产物(1)

mRNA Protein Name
NM_000906.4 NP_000897.3 atrial natriuretic peptide receptor 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables guanylate cyclase activity IDA
IDA: 通过直接分析推断
1672777 GOA
enables hormone binding IPI
IPI: 通过物理相互作用推断
12547834 GOA
enables natriuretic peptide receptor activity IDA
IDA: 通过直接分析推断
1660465 GOA
enables peptide hormone binding IPI
IPI: 通过物理相互作用推断
1660465 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cGMP biosynthetic process IDA
IDA: 通过直接分析推断
1672777 GOA
involved in receptor guanylyl cyclase signaling pathway IDA
IDA: 通过直接分析推断
1672777 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of receptor complex IDA
IDA: 通过直接分析推断
23382219 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NPR1 蛋白结构

ANF_receptor

ANF_receptor: Receptor family ligand binding region (54 - 415)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (559 - 799)

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (867 - 1052)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1061 a.a.
蛋白主名 其他名称

atrial natriuretic peptide receptor 1

ANP-A

关联疾病

疾病名称 别名
Hypertensive Heart Disease
Congestive Heart Failure

Congestive Heart Disease

Heart Failure

Cardiac Failure Congestive

Chf

Weak Heart

Heart Failure Congestive

Ccf - [Congestive Cardiac Failure]

Chf - [Congestive Heart Failure]

Congestive Cardiac Diseases

Congested Heart Failure

Congestive Cardiac Failure

Cardiac Anasarca

Cardiac Oedema

Cardiac Stasis

Cardiovascular Oedema

Cardiac Hydrops

Congestive Failure

Heart Congestion

Heart Fluid

Oedematous Heart
Malt Worker'S Lung

Alveolitis Due To Aspergillus Clavatus

Malt Worker Lung

Malt Workers' Lung

Malt-Workers' Lung

Malt Fever

Malt House Workers' Cough

Malt-Workers' Alveolitis

Malt-Workers' Lung Disease

Alveolitis Due To Aspergillus Fumigatus

Extrinsic Allergic Alveolitis Due To Aspergillus Spp
Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration
Acromesomelic Dysplasia

Acromesomelic Dwarfism

Dysplasia, Acromesomelic

Acromesomelic Dysplasia Hunter-Thompson Type
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1
Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P990951 Vixticibart / Phase 2
HY-P990921 Imelciment / Phase 1
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P1419 AP 811 Antagonist 98.07% 否
HY-153650 JS11 Inhibitor 99.22% 否
HY-177062 NPRA agonist-11 Agonist / 否
HY-P1419A AP 811 acetate Antagonist / 否
HY-RS09497 NPR1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18627 Npr1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25113 Npr1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991121 Baloncibart Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NPR1 VGNC VGNC:75388
Canis familiaris NPR1 VGNC VGNC:43928
Bos taurus NPR1 VGNC VGNC:32213
Rattus norvegicus NPR1 RGD RGD:3195
Felis catus NPR1 VGNC VGNC:107906
Mus musculus NPR1 MGD MGI:97371
Macaca fascicularis NPR1 NCBI NCBI:102143449
Others NPR1 NCBI
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