RBMXL1 - RBMX like 1 Gene

中文名称：RBMX 样 1

种属: Homo sapiens

同用名: RBM1

关于 RBMXL1

功能概要

该基因代表了一个位于 X 染色体上的 RNA 结合基序蛋白 X-linked (RBMX) 的逆转录基因。虽然与 RBMX 基因座相比，编码序列中的所有内含子都被加工掉了，但 ORF 是完整的，并且具有特异性在此位置转录的证据。通过在所有携带它的旧世界猴子中纯化选择来保存 ORF，表明该基因座可能具有功能，可能在 X 染色体基因沉默的雄性减数分裂期间或在精子发生的单倍体阶段。该基因与 1 号染色体上的半胱氨酸结合-β 裂解酶 2 基因座共享 5' 外显子结构，但编码序列不重叠。可变剪接导致两种转录本变体。[RefSeq 提供，2009 年 6 月]

This gene represents a retrogene of RNA binding motif protein, X-linked (RBMX), which is located on chromosome X. While all introns in the coding sequence have been processed out compared to the RBMX locus, the ORF is intact and there is specific evidence for transcription at this location. The preservation of the ORF by purifying selection in all Old World monkeys carrying it suggests that this locus is likely to be functional, possibly during male meiosis when X chromosomal genes are silenced or during haploid stages of spermatogenesis. This gene shares 5' exon structure with the cysteine conjugate-beta lyase 2 locus on chromosome 1, but the coding sequences are non-overlapping. Alternative splicing results in two transcript variants. [provided by RefSeq, Jun 2009]