2. Gene
  3. ENG - Eng endoglin Gene

ENG - Eng endoglin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 497010 | 基因类型: protein coding

关于 ENG

功能概要

Enables type II transforming growth factor beta receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of collagen biosynthetic process; and positive regulation of macromolecule metabolic process. Located in cell surface and extracellular space. Used to study congestive heart failure; pre-eclampsia; and renal fibrosis. Biomarker of cholestasis; congestive heart failure; hepatocellular carcinoma; hypertension (multiple); and renal fibrosis. Human ortholog(s) of this gene implicated in arteriovenous malformation; arteriovenous malformations of the brain; breast cancer; hereditary hemorrhagic telangiectasia; and intracranial aneurysm. Orthologous to human ENG (endoglin). [provided by Alliance of Genome Resources, Apr 2022]

ENG 基因产物(1)

mRNA Protein Name
NM_001010968.3 NP_001010968.1 endoglin precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables type II transforming growth factor beta receptor binding IPI
IPI: 通过物理相互作用推断
21146604 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in bone development IEP
IEP: 通过表达模式推断
20865666 RGD
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
22941949 RGD
involved in extracellular matrix constituent secretion IMP
IMP: 通过突变表型推断
15539634 RGD
involved in positive regulation of collagen biosynthetic process IMP
IMP: 通过突变表型推断
20156938 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
21146604 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
21146604 RGD
involved in regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
17376778 RGD
involved in response to transforming growth factor beta IEP
IEP: 通过表达模式推断
22941949 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
20156938 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
15537649 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
19075097 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

endoglin

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04374 ENG Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens ENG NCBI NCBI:2022
Mus musculus ENG NCBI NCBI:13805
Macaca mulatta ENG NCBI NCBI:706569
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