Ern1 - endoplasmic reticulum to nucleus signaling 1 Gene

中文名称：内质网到细胞核信号 1

种属: Rattus norvegicus

同用名: RGD1559716

关于 Ern1

功能概要

该基因编码的蛋白可启动 HSP90 蛋白结合活性。参与细胞对葡萄糖刺激的反应；细胞对过氧化氢的反应；和细胞对锰离子的反应。预测位于内质网膜；线粒体；和核内膜。预计是内质网膜的组成部分。预计是 AIP1-IRE1 复合体的一部分； IRE1-RACK1-PP2A 复合体；和 IRE1-TRAF2-ASK1 复合体。该基因的人类直系同源物与肝细胞癌有关。与人类 ERN1（内质网到细胞核信号转导 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables HSP90 protein binding activity. Involved in cellular response to glucose stimulus; cellular response to hydrogen peroxide; and cellular response to manganese ion. Predicted to be located in endoplasmic reticulum membrane; mitochondrion; and nuclear inner membrane. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be part of AIP1-IRE1 complex; IRE1-RACK1-PP2A complex; and IRE1-TRAF2-ASK1 complex. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1). [provided by Alliance of Genome Resources, Apr 2022]