2. Gene
  3. Mapk3 - mitogen activated protein kinase 3 Gene

Mapk3 - mitogen activated protein kinase 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：有丝分裂原活化蛋白激酶 3

种属: Rattus norvegicus

同用名: p44; ERK1; ERT2; MNK1; Erk-1; Esrk1; MAPK1; Prkm3; p44erk1; p44mapk

基因 ID: 50689 | 基因类型: protein coding

关于 Mapk3

Primary_assembly 1: 181,366,637-181,372,863 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 197 orthologues, 21 paralogues and is associated with 67 phenotypes. Biased expression in Lung (RPKM 21.4), Brain (RPKM 14.7) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 ATP 绑定活动； MAP 激酶活性；和支架蛋白结合活性。参与多个过程，包括花生四烯酸代谢过程；蜕化；和肽基丝氨酸磷酸化。位于caveola;胞质溶胶；和核质。部分含蛋白质复合物。用于研究胃溃疡；大脑中动脉梗塞; 2型糖尿病；和输尿管梗阻。该基因的人类直系同源物与结肠腺癌有关；结直肠腺癌；子宫内膜腺癌；胰腺导管癌；和肺动脉高压。与人 MAPK3（丝裂原活化蛋白激酶 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity; MAP kinase activity; and scaffold protein binding activity. Involved in several processes, including arachidonic acid metabolic process; decidualization; and peptidyl-serine phosphorylation. Located in caveola; cytosol; and nucleoplasm. Part of protein-containing complex. Used to study gastric ulcer; middle cerebral artery infarction; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; endometrial adenocarcinoma; pancreatic ductal carcinoma; and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Mapk3 基因产物(1)

mRNA Protein Name
NM_017347.3 NP_059043.2 mitogen-activated protein kinase 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
15027896 RGD
enables MAP kinase activity IDA
IDA: 通过直接分析推断
7889942 RGD
enables MAP kinase activity IMP
IMP: 通过突变表型推断
16955078 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15781236 RGD
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
20455999 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in MAPK cascade IMP
IMP: 通过突变表型推断
17310240 RGD
involved in arachidonate metabolic process IEP
IEP: 通过表达模式推断
15027896 RGD
involved in cellular response to toxic substance IDA
IDA: 通过直接分析推断
12487375 RGD
involved in decidualization IDA
IDA: 通过直接分析推断
21248290 RGD
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
12072413 RGD
involved in peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
16955078 RGD
involved in positive regulation of translation IMP
IMP: 通过突变表型推断
15027896 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
15027896 RGD
involved in protein-containing complex assembly IMP
IMP: 通过突变表型推断
7889942 RGD
involved in response to toxic substance IDA
IDA: 通过直接分析推断
17651772 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in caveola IDA
IDA: 通过直接分析推断
24567387 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
24567387 RGD
located in nucleoplasm IDA
IDA: 通过直接分析推断
7889942 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
24567387 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
15781236 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Mapk3 蛋白结构

STKc_ERK1_2_like

STKc_ERK1_2_like: cd07849 (36 - 396)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase 3

MAP kinase 1

MAP kinase 3

MAPK 1

MAPK 3

extracellular signal-regulated kinase 1

insulin-stimulated MAP2 kinase

microtubule-associated protein 2 kinase

mitogen-activated 3

mitogen-activated protein kinase 1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08113 MAPK3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS08114 Mapk3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS08115 Mapk3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mapk3 NCBI NCBI:5595
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