TXNDC12 - thioredoxin domain containing 12 Gene

中文名称：含硫氧还蛋白结构域 12

种属: Homo sapiens

同用名: AG1; AGR1; ERP16; ERP18; ERP19; TLP19; hAG-1; PDIA16; hTLP19

关于 TXNDC12

功能概要

该基因编码硫氧还蛋白超家族的一个成员。该家族成员的特征在于称为硫氧还蛋白折叠的保守活性基序，可催化二硫键形成和异构化。这种蛋白质定位于内质网并具有单一的非典型活性基序。编码的蛋白质主要参与催化天然二硫键形成，并显示出类似于蛋白质二硫键异构酶的活性。这种蛋白质可能在防御内质网应激中发挥作用。交替剪接导致编码和非编码变体。[RefSeq 提供，2012 年 3 月]

This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]