2. Gene
  3. ANGPTL4 - angiopoietin like 4 Gene

ANGPTL4 - angiopoietin like 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：血管生成素样 4

种属: Homo sapiens

同用名: NL2; ARP4; FIAF; HARP; PGAR; HFARP; TGQTL; UNQ171; pp1158

基因 ID: 51129 | 基因类型: protein coding

关于 ANGPTL4

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,364,155-8,374,370 (from NCBI)

This gene has 11 transcripts (splice variants), 240 orthologues, 25 paralogues and is associated with 1 phenotype. Broad expression in liver (RPKM 42.4), fat (RPKM 23.7) and 17 other tissues.

功能概要

该基因编码含有 C 端纤维蛋白原结构域的糖基化分泌蛋白。编码的蛋白质由过氧化物酶体增殖激活剂诱导，并作为调节葡萄糖稳态、脂质代谢和胰岛素敏感性的血清激素发挥作用。该蛋白还可以作为血管内皮细胞的凋亡存活因子，通过抑制血管生长和肿瘤细胞侵袭来预防转移。 C 末端结构域可以从全长分泌蛋白中通过蛋白水解方式切割下来。该基因表达减少与 2 型糖尿病有关。可变剪接导致多个转录本变体。该基因以前称为 ANGPTL2，但已重命名为 ANGPTL4。[RefSeq 提供，2013 年 9 月]

This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and Insulin sensitivity. This protein can also act as an Apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]

ANGPTL4 基因产物(2)

mRNA Protein Name
NM_001039667.3 NP_001034756.1 angiopoietin-related protein 4 isoform b precursor
NM_139314.3 NP_647475.1 angiopoietin-related protein 4 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
19028676 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21397862 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
10698685 GOA
involved in negative regulation of lipoprotein lipase activity IDA
IDA: 通过直接分析推断
19542565 GOA
involved in protein unfolding IDA
IDA: 通过直接分析推断
29899144 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
10698685 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
10698685 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ANGPTL4 蛋白结构

Fibrinogen_C

Fibrinogen_C: Fibrinogen beta and gamma chains, C-terminal globular domain (185 - 399)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
蛋白主名 其他名称

angiopoietin-related protein 4

PPARG angiopoietin related protein

ANGPTL4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ANGPTL4 Q9BY76 ITGB5 Homo sapiens P18084
Anti Bait CoIP
21397862
种属内
ANGPTL4 Q9BY76 NMT2 Homo sapiens O60551
Anti Tag CoIP
33961781
种属内
ANGPTL4 Q9BY76 LPL Homo sapiens P06858
ELISA
19318355
种属内
ANGPTL4 Q9BY76 ANGPTL4 Homo sapiens Q9BY76
GMS
19028676
种属内
ANGPTL4 Q9BY76 PM20D2 Homo sapiens Q8IYS1
Anti Tag CoIP
33961781
种属内
ANGPTL4 Q9BY76 AASDHPPT Homo sapiens Q9NRN7
Anti Tag CoIP
33961781
种属内
ANGPTL4 Q9BY76 PM20D2 Homo sapiens Q8IYS1
Anti Tag CoIP
28514442
种属内
ANGPTL4 Q9BY76 AASDHPPT Homo sapiens Q9NRN7
Anti Tag CoIP
28514442
种属内
ANGPTL4 Q9BY76 ITGB1 Homo sapiens P05556
PLA
21397862
种属内
ANGPTL4 Q9BY76 NMT2 Homo sapiens O60551
Anti Tag CoIP
28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ANGPTL4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7507 ANGPTL4/Angiopoietin-related 4 Protein, Human (HEK293, His) Q9BY76-1(P166-S406) ≥95%
HY-P700562 ANGPTL4/Angiopoietin-related 4 Protein, Human (GST) Q9BY76-1 (V28-E403) ≥95%

ANGPTL4 抗体

目录号 产品名 应用 反应物种
HY-P82345 Angiopoietin Like 4 Antibody (YA2090) WB Human

关联疾病

疾病名称 别名
Plasma Triglyceride Level Quantitative Trait Locus

TGQTL

Plasma Triglyceride Level Qtl, Low
Gastric Antral Vascular Ectasia

Watermelon Stomach

Gave
Familial Hyperlipidemia

Familial Hyperlipoproteinemia

Hyperlipidaemia

Hyperlipoproteinemias

Hyperlipidemia

Hyperlipemia

Hyperlipidemias
Endometrial Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of Endometrium
Hyperlipoproteinemia, Type I

Lipoprotein Lipase Deficiency

Familial Chylomicronemia Syndrome

Lpl Deficiency

Hyperchylomicronemia, Familial

Hyperlipemia, Idiopathic, Burger-Grutz Type

Hyperlipemia, Essential Familial

Lipase D Deficiency

Lipd Deficiency

Hyperlipoproteinemia, Type Ia

Chylomicronemia, Familial

High Density Lipoprotein Cholesterol Level Qtl 11

Hyperlipoproteinemia Type 1

Hyperlipoproteinemia 1

HLPP1

Lipoprotein Lipase

Hyperlipoproteinemia Type I

Familial Hyperchylomicronemia Syndrome
Mesenteric Lymphadenitis

Mesenteric Adenitis
Hypobetalipoproteinemia, Familial, 2

Familial Hypobetalipoproteinemia 2

FHBL2

Hypolipidemia, Familial, Combined

Combined Familial Hypolipidemia

Combined Hypobetalipoproteinemia Familial

Hypobetalipoproteinemia, Familial, Type 2
Familial Lipoprotein Lipase Deficiency

Familial Lpl Deficiency

Familial Hyperchylomicronemia

Hyperlipoproteinemia Type I

Familial Hyperlipoproteinemia Type I

Hyperchylomicronemia

Burger-Grutz Syndrome

Endogenous Hypertriglyceridaemia

Familial Fat-Induced Hypertriglyceridemia

Lipd Deficiency

Lpl Deficiency

Lipase D Deficiency

Lipoprotein Lipase Deficiency, Familial

Familial Chylomicronemia Syndrome

Fredrickson Type I Hyperlipoproteinemia

Fredrickson Type I Lipaemia

Hypercholesterinaemic Xanthomatosis

Mixed Hyperglyceridemia

Lipoprotein Lipase Deficiency

Type I Hyperlipoproteinemia

Hyperlipoproteinemia Type Ia

Familial Hyperlipo-Proteinemia Type 1
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome

Ns - [Nephrotic Syndrome]

Nephrosis Syndrome

Nephrosis Nos

Glomerular Lesion Nephrosis
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Diabetes Mellitus

Diabetes
Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990335 Anti-ANGPTL4 Antibody Inhibitor 97.18% 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ANGPTL4 VGNC VGNC:37860
Mus musculus ANGPTL4 MGD MGI:1888999
Rattus norvegicus ANGPTL4 RGD RGD:735058
Felis catus ANGPTL4 VGNC VGNC:59780
Bos taurus ANGPTL4 VGNC VGNC:25893
Macaca mulatta ANGPTL4 VGNC VGNC:108464
Macaca fascicularis ANGPTL4 NCBI NCBI:102135390
Others ANGPTL4 NCBI
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