ANGPTL4 - angiopoietin like 4 Gene

中文名称：血管生成素样 4

种属: Homo sapiens

同用名: NL2; ARP4; FIAF; HARP; PGAR; HFARP; TGQTL; UNQ171; pp1158

基因 ID: 51129 | 基因类型: protein coding

关于 ANGPTL4

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,364,155-8,374,370 (from NCBI)

This gene has 11 transcripts (splice variants), 240 orthologues, 25 paralogues and is associated with 1 phenotype. Broad expression in liver (RPKM 42.4), fat (RPKM 23.7) and 17 other tissues.

功能概要

该基因编码含有 C 端纤维蛋白原结构域的糖基化分泌蛋白。编码的蛋白质由过氧化物酶体增殖激活剂诱导，并作为调节葡萄糖稳态、脂质代谢和胰岛素敏感性的血清激素发挥作用。该蛋白还可以作为血管内皮细胞的凋亡存活因子，通过抑制血管生长和肿瘤细胞侵袭来预防转移。 C 末端结构域可以从全长分泌蛋白中通过蛋白水解方式切割下来。该基因表达减少与 2 型糖尿病有关。可变剪接导致多个转录本变体。该基因以前称为 ANGPTL2，但已重命名为 ANGPTL4。[RefSeq 提供，2013 年 9 月]

This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and Insulin sensitivity. This protein can also act as an Apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]

ANGPTL4 基因产物(2)

mRNA	Protein	Name
NM_001039667.3	NP_001034756.1	angiopoietin-related protein 4 isoform b precursor
NM_139314.3	NP_647475.1	angiopoietin-related protein 4 isoform a precursor

ANGPTL4 蛋白结构

Fibrinogen_C

0
100
200
300
406 a.a.

蛋白主名

其他名称

angiopoietin-related protein 4

PPARG angiopoietin related protein

重组 ANGPTL4 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7507	ANGPTL4/Angiopoietin-related 4 Protein, Human (HEK293, His)	Q9BY76-1 (P166-S406)	≥95%
HY-P700562	ANGPTL4/Angiopoietin-related 4 Protein, Human (GST)	Q9BY76 (V28-E403)	≥95%

关联疾病

疾病名称

别名

Plasma Triglyceride Level Quantitative Trait Locus

TGQTL

Plasma Triglyceride Level Qtl, Low

Gastric Antral Vascular Ectasia

Watermelon Stomach

Gave

Familial Hyperlipidemia

Familial Hyperlipoproteinemia	Hyperlipidaemia
Hyperlipoproteinemias	Hyperlipidemia
Hyperlipemia	Hyperlipidemias

Endometrial Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of Endometrium

Hyperlipoproteinemia, Type I

Lipoprotein Lipase Deficiency	Familial Chylomicronemia Syndrome
Lpl Deficiency	Hyperchylomicronemia, Familial
Hyperlipemia, Idiopathic, Burger-Grutz Type	Hyperlipemia, Essential Familial
Lipase D Deficiency	Lipd Deficiency
Hyperlipoproteinemia, Type Ia	Chylomicronemia, Familial
High Density Lipoprotein Cholesterol Level Qtl 11	Hyperlipoproteinemia Type 1
Hyperlipoproteinemia 1	HLPP1
Lipoprotein Lipase	Hyperlipoproteinemia Type I
Familial Hyperchylomicronemia Syndrome

Mesenteric Lymphadenitis

Mesenteric Adenitis

Hypobetalipoproteinemia, Familial, 2

Familial Hypobetalipoproteinemia 2	FHBL2
Hypolipidemia, Familial, Combined	Combined Familial Hypolipidemia
Combined Hypobetalipoproteinemia Familial	Hypobetalipoproteinemia, Familial, Type 2

Familial Lipoprotein Lipase Deficiency

Familial Lpl Deficiency	Familial Hyperchylomicronemia
Hyperlipoproteinemia Type I	Familial Hyperlipoproteinemia Type I
Hyperchylomicronemia	Burger-Grutz Syndrome
Endogenous Hypertriglyceridaemia	Familial Fat-Induced Hypertriglyceridemia
Lipd Deficiency	Lpl Deficiency
Lipase D Deficiency	Lipoprotein Lipase Deficiency, Familial
Familial Chylomicronemia Syndrome	Fredrickson Type I Hyperlipoproteinemia
Fredrickson Type I Lipaemia	Hypercholesterinaemic Xanthomatosis
Mixed Hyperglyceridemia	Lipoprotein Lipase Deficiency
Type I Hyperlipoproteinemia	Hyperlipoproteinemia Type Ia
Familial Hyperlipo-Proteinemia Type 1

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diabetes Mellitus

Diabetes

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-116247	ST247	Agonist	/	否
HY-RS00693	ANGPTL4 Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ANGPTL4	VGNC	VGNC:37860
Mus musculus	ANGPTL4	MGD	MGI:1888999
Rattus norvegicus	ANGPTL4	RGD	RGD:735058
Felis catus	ANGPTL4	VGNC	VGNC:59780
Bos taurus	ANGPTL4	VGNC	VGNC:25893
Macaca mulatta	ANGPTL4	VGNC	VGNC:108464
Macaca fascicularis	ANGPTL4	NCBI
Others	ANGPTL4	NCBI

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ANGPTL4 - angiopoietin like 4 Gene

关于 ANGPTL4

功能概要

ANGPTL4 基因产物(2)

ANGPTL4 蛋白结构

重组 ANGPTL4 蛋白

关联疾病

直系同源

热门区域

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ANGPTL4 - angiopoietin like 4 Gene

关于 ANGPTL4

功能概要

ANGPTL4 基因产物(2)

ANGPTL4 蛋白结构

重组 ANGPTL4 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z