1. Gene
  2. TUBE1 - tubulin epsilon 1 Gene

TUBE1 - tubulin epsilon 1 Gene

中文名称:微管蛋白ε1

种属: Homo sapiens

同用名: TUBE; dJ142L7.2

基因 ID: 51175 | 基因类型: protein coding

关于 TUBE1

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:112,070,663-112,087,482 (from NCBI)

This gene has 11 transcripts (splice variants), 209 orthologues and 23 paralogues. Broad expression in testis (RPKM 21.9), endometrium (RPKM 10.2) and 25 other tissues.

功能概要

该基因编码微管蛋白超家族的一个成员。这种蛋白质定位于与中心体复制后两个中心粒中较旧的中心粒相关的中心粒亚远侧附属物。这种蛋白质在中心粒复制过程中的微管组织中起着核心作用。在 5 号染色体上发现了该基因的假基因。[RefSeq 提供,2009 年 1 月]

This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Jan 2009]

TUBE1 基因产物(1)

mRNA Protein Name
NM_016262.5 NP_057346.1 tubulin epsilon chain

TUBE1 蛋白结构

Tubulin

Tubulin: Tubulin/FtsZ family, GTPase domain (5 - 220)

Tubulin_C

Tubulin_C: Tubulin C-terminal domain (294 - 413)

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  • 475 a.a.
蛋白主名 其他名称

tubulin epsilon chain

epsilon-tubulin

关联疾病

疾病名称 别名
Bladder Exstrophy

Exstrophy Of The Bladder

Classic Exstrophy Of The Bladder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus TUBE1 VGNC VGNC:36511
Mus musculus TUBE1 MGD MGI:1919174
Canis familiaris TUBE1 VGNC VGNC:54383
Rattus norvegicus TUBE1 RGD RGD:1306048
Macaca mulatta TUBE1 VGNC VGNC:79284
Felis catus TUBE1 VGNC VGNC:66703