2. Gene
  3. CPA4 - carboxypeptidase A4 Gene

CPA4 - carboxypeptidase A4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：羧肽酶 A4

种属: Homo sapiens

同用名: CPA3

基因 ID: 51200 | 基因类型: protein coding

关于 CPA4

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,293,161-130,324,180 (from NCBI)

This gene has 11 transcripts (splice variants), 126 orthologues and 8 paralogues. Biased expression in skin (RPKM 24.3) and esophagus (RPKM 4.3).

功能概要

该基因是羧肽酶 A/B 亚家族的成员，与其他三个家族成员位于 7 号染色体上的簇中。羧肽酶是含锌外肽酶，可催化羧基末端氨基酸的释放，合成如下由蛋白水解裂解激活的酶原。该基因可能参与组蛋白超乙酰化途径。它带有印迹，可能是前列腺癌侵袭性的一个强有力的候选基因。[RefSeq 提供，2008 年 7 月]

This gene is a member of the Carboxypeptidase A/B subfamily, and it is located in a cluster with three Other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal Amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate Cancer aggressiveness. [provided by RefSeq, Jul 2008]

CPA4 基因产物(2)

mRNA Protein Name
NM_001163446.2 NP_001156918.1 carboxypeptidase A4 isoform 2 precursor
NM_016352.4 NP_057436.2 carboxypeptidase A4 isoform 1 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables metallocarboxypeptidase activity IDA
IDA: 通过直接分析推断
20385563 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23746805 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in hormone catabolic process IDA
IDA: 通过直接分析推断
20385563 GOA
involved in peptide catabolic process IDA
IDA: 通过直接分析推断
20385563 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
20385563 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CPA4 蛋白结构

Propep_M14

Propep_M14: Carboxypeptidase activation peptide (27 - 102)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (131 - 407)

  • 0
  • 100
  • 200
  • 300
  • 421 a.a.
蛋白主名 其他名称

carboxypeptidase A4

carboxypeptidase A3

关联疾病

疾病名称 别名
Thiopental Allergy

Penthiobarbital Allergy

Pentothiobarbital Allergy
Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis

EOE1

Esophagitis, Eosinophilic

Ee
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03083 CPA4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19589 Cpa4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26086 Cpa4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CPA4 VGNC VGNC:61114
Bos taurus CPA4 VGNC VGNC:107220
Mus musculus CPA4 MGD MGI:1919041
Macaca mulatta CPA4 VGNC VGNC:71411
Canis familiaris CPA4 VGNC VGNC:39545
Rattus norvegicus CPA4 RGD RGD:1563619
Others CPA4 NCBI
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