2. Gene
  3. ZDHHC2 - zinc finger DHHC-type palmitoyltransferase 2 Gene

ZDHHC2 - zinc finger DHHC-type palmitoyltransferase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：锌指 DHHC 型棕榈酰转移酶 2

种属: Homo sapiens

同用名: DHHC2; ZNF372

基因 ID: 51201 | 基因类型: protein coding

关于 ZDHHC2

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:17,156,482-17,224,799 (from NCBI)

This gene has 4 transcripts (splice variants), 210 orthologues and 17 paralogues. Ubiquitous expression in thyroid (RPKM 18.6), adrenal (RPKM 10.6) and 24 other tissues.

功能概要

启用蛋白质同二聚化活性和蛋白质-半胱氨酸 S-棕榈酰转移酶活性。参与多个过程，包括肽基-L-半胱氨酸 S-棕榈酰化；调节蛋白质分解代谢过程；和调节蛋白质在质膜上的定位。位于高尔基体和内质网膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein homodimerization activity and protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including peptidyl-L-cysteine S-palmitoylation; regulation of protein catabolic process; and regulation of protein localization to plasma membrane. Located in Golgi apparatus and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

ZDHHC2 基因产物(3)

mRNA Protein Name
NM_001362988.2 NP_001349917.1 palmitoyltransferase ZDHHC2 isoform 2
NM_001362989.2 NP_001349918.1 palmitoyltransferase ZDHHC2 isoform 3
NM_016353.5 NP_057437.1 palmitoyltransferase ZDHHC2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables palmitoyltransferase activity IDA
IDA: 通过直接分析推断
23034182 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
23793055 GOA
enables protein-cysteine S-palmitoyltransferase activity IDA
IDA: 通过直接分析推断
23793055 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in peptidyl-L-cysteine S-palmitoylation IDA
IDA: 通过直接分析推断
23793055 GOA
involved in peptidyl-L-cysteine S-palmitoylation IMP
IMP: 通过突变表型推断
18296695 GOA
involved in protein localization to membrane raft IMP
IMP: 通过突变表型推断
25589740 GOA
involved in protein palmitoylation IDA
IDA: 通过直接分析推断
23034182 GOA
involved in regulation of cell-cell adhesion IMP
IMP: 通过突变表型推断
18508921 GOA
involved in regulation of protein catabolic process IMP
IMP: 通过突变表型推断
18508921 GOA
involved in regulation of protein localization to plasma membrane IMP
IMP: 通过突变表型推断
18296695 GOA
involved in synapse assembly IMP
IMP: 通过突变表型推断
25589740 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
16647879 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
16647879 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
22034844 GOA
is active in postsynaptic recycling endosome IMP
IMP: 通过突变表型推断
25589740 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZDHHC2 蛋白结构

DHHC

DHHC: DHHC palmitoyltransferase (67 - 246)

  • 0
  • 100
  • 200
  • 300
  • 367 a.a.
蛋白主名 其他名称

palmitoyltransferase ZDHHC2

DHHC-2

关联疾病

疾病名称 别名
Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever
Arthrogryposis, Distal, Type 2a

Freeman-Sheldon Syndrome

Craniocarpotarsal Dystrophy

Craniocarpotarsal Dysplasia

DA2A

Whistling Face-Windmill Vane Hand Syndrome

Fss

Distal Arthrogryposis Type 2a

Whistling Face Syndrome

Freeman-Burian Syndrome

Arthrogryposis Distal Type 2a

Distal Arthrogryposis, Type 2a

Fbs

Arthrogryposis, Distal, 2a
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16019 ZDHHC2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ZDHHC2 MGD MGI:1923452
Macaca mulatta ZDHHC2 VGNC VGNC:79142
Bos taurus ZDHHC2 VGNC VGNC:37135
Rattus norvegicus ZDHHC2 RGD RGD:628681
Felis catus ZDHHC2 VGNC VGNC:67209
Others ZDHHC2 NCBI
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