2. Gene
  3. CRIM1 - cysteine rich transmembrane BMP regulator 1 Gene

CRIM1 - cysteine rich transmembrane BMP regulator 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：富半胱氨酸的跨膜 BMP 调节因子 1

种属: Homo sapiens

同用名: S52; CRIM-1

基因 ID: 51232 | 基因类型: protein coding

关于 CRIM1

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:36,355,778-36,551,135 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 133 orthologues, 19 paralogues and is associated with 2 phenotypes. Broad expression in placenta (RPKM 93.7), fat (RPKM 55.7) and 23 other tissues.

功能概要

该基因编码的跨膜蛋白包含六个富含半胱氨酸的重复结构域和一个胰岛素样生长因子结合结构域。编码的蛋白质可能通过与转化生长因子 β 家族成员 (如骨形态发生蛋白) 的相互作用在组织发育中发挥作用。[RefSeq 提供，2010 年 11 月]

This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]

CRIM1 基因产物(1)

mRNA Protein Name
NM_016441.3 NP_057525.1 cysteine-rich motor neuron 1 protein precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables PDZ domain binding IDA
IDA: 通过直接分析推断
23209302 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within negative regulation of BMP signaling pathway IMP
IMP: 通过突变表型推断
21743293 GOA
acts upstream of negative regulation of osteoblast differentiation IMP
IMP: 通过突变表型推断
21042576 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CRIM1 蛋白结构

VWC

VWC: von Willebrand factor type C domain (336 - 390)

VWC

VWC: von Willebrand factor type C domain (403 - 456)

Antistasin

Antistasin: Antistasin family (469 - 498)

Antistasin

Antistasin: Antistasin family (505 - 532)

Antistasin

Antistasin: Antistasin family (539 - 564)

Antistasin

Antistasin: Antistasin family (567 - 592)

VWC

VWC: von Willebrand factor type C domain (611 - 662)

VWC

VWC: von Willebrand factor type C domain (684 - 734)

VWC

VWC: von Willebrand factor type C domain (757 - 808)

VWC

VWC: von Willebrand factor type C domain (819 - 873)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1036 a.a.
蛋白主名 其他名称

cysteine-rich motor neuron 1 protein

cysteine rich transmembrane BMP regulator 1 (chordin-like)

关联疾病

疾病名称 别名
Macrophthalmia, Colobomatous, With Microcornea

MACOM

Colobomatous Macrophthalmia-Microcornea Syndrome

Macom Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03174 CRIM1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21541 Crim1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28059 Crim1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CRIM1 VGNC VGNC:27710
Mus musculus CRIM1 MGD MGI:1354756
Felis catus CRIM1 VGNC VGNC:61178
Canis familiaris CRIM1 VGNC VGNC:39612
Macaca mulatta CRIM1 VGNC VGNC:106144
Rattus norvegicus CRIM1 RGD RGD:1308710
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