2. Gene
  3. CDK16 - cyclin dependent kinase 16 Gene

CDK16 - cyclin dependent kinase 16 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶 16

种属: Homo sapiens

同用名: PCTK1; PCTAIRE; PCTAIRE1; PCTGAIRE

基因 ID: 5127 | 基因类型: protein coding

关于 CDK16

Cytogenetic location: Xp11.3 Genomic coordinates (GRCh38): X:47,218,303-47,229,997 (from NCBI)

This gene has 22 transcripts (splice variants), 174 orthologues, 26 paralogues and is associated with 1 phenotype. Ubiquitous expression in heart (RPKM 14.6), brain (RPKM 14.2) and 25 other tissues.

功能概要

该基因编码的蛋白质属于蛋白激酶 ser/thr 家族的 cdc2/cdkx 亚家族。它可能在终末分化细胞的信号转导级联中发挥作用；在胞吐作用中；以及从内质网运输分泌物。该基因被认为可以逃避 X 失活。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 12 月]

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]

CDK16 基因产物(15)

mRNA Protein Name
XM_047442152.1 XP_047298108.1 cyclin-dependent kinase 16 isoform X5
NM_006201.5 NP_006192.1 cyclin-dependent kinase 16 isoform 1
XM_011543922.2 XP_011542224.1 cyclin-dependent kinase 16 isoform X4
XM_011543926.2 XP_011542228.1 cyclin-dependent kinase 16 isoform X7
NM_001170460.2 NP_001163931.1 cyclin-dependent kinase 16 isoform 3
NM_033018.4 NP_148978.2 cyclin-dependent kinase 16 isoform 2
XM_011543920.4 XP_011542222.1 cyclin-dependent kinase 16 isoform X1
XM_011543923.3 XP_011542225.1 cyclin-dependent kinase 16 isoform X6
XM_011543925.3 XP_011542227.1 cyclin-dependent kinase 16 isoform X7
NM_033019.1
XM_047442153.1 XP_047298109.1 cyclin-dependent kinase 16 isoform X8
XM_017029569.2 XP_016885058.1 cyclin-dependent kinase 16 isoform X3
XM_011543924.3 XP_011542226.1 cyclin-dependent kinase 16 isoform X7
XM_047442154.1 XP_047298110.1 cyclin-dependent kinase 16 isoform X9
XM_011543921.2 XP_011542223.1 cyclin-dependent kinase 16 isoform X2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12154078 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
22184064 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of autophagy IDA
IDA: 通过直接分析推断
32098961 GOA
involved in regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
22798068 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: 通过物理相互作用推断
19524571 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
22798068 GOA
located in cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
22184064 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
19524571 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDK16 蛋白结构

Pkinase

Pkinase: Protein kinase domain (166 - 446)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 496 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 16

PCTAIRE-motif protein kinase 1

cell division protein kinase 16

serine/threonine-protein kinase PCTAIRE-1

testis secretory sperm-binding protein Li 224n

CDK16 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CDK16 Q00536 CCNYL1 Homo sapiens Q8N7R7
Anti Tag CoIP
25852190
种属内
CDK16 Q00536 CCNYL1 Homo sapiens Q8N7R7
Anti Tag CoIP
26496610
种属内
CDK16 Q00536 CCNYL1 Homo sapiens Q8N7R7
Anti Tag CoIP
33961781
种属内
CDK16 Q00536 CCNYL1 Homo sapiens Q8N7R7
Y2H
22184064
种属内
CDK16 Q00536 CCNYL1 Homo sapiens Q8N7R7
Pull Down
32707033
种属内
CDK16 Q00536 ZBTB14 Homo sapiens O43829
Validated Y2H
25416956
种属内
CDK16 Q00536 CCNY Homo sapiens Q8ND76
Anti Tag CoIP
33961781
种属内
CDK16 Q00536 CCNY Homo sapiens Q8ND76
Y2H
22184064
种属内
CDK16 Q00536 CCNY Homo sapiens Q8ND76
Pull Down
32707033
种属内
CDK16 Q00536 CCNY Homo sapiens Q8ND76-1
Protein Kinase Assay
22184064
种属内
CDK16 Q00536 CCNY Homo sapiens Q8ND76-1
Anti Tag CoIP
22184064
种属内
CDK16 Q00536 YWHAZ Homo sapiens P63104
Anti Tag CoIP
25852190
种属内
CDK16 Q00536 YWHAZ Homo sapiens P63104
Pull Down
12154078
种属内
CDK16 Q00536 YWHAE Homo sapiens P62258
Anti Tag CoIP
25852190
种属内
CDK16 Q00536 YWHAE Homo sapiens P62258
Pull Down
32707033
种属内
CDK16 Q00536 YWHAE Homo sapiens P62258
Crosslink
36931259
种属内
CDK16 Q00536 CDK17 Homo sapiens Q00537
Anti Tag CoIP
33961781
种属内
CDK16 Q00536 CDK17 Homo sapiens Q00537
Anti Tag CoIP
28514442
种属内
CDK16 Q00536 SEC23A Homo sapiens Q15436
Pull Down
16091426
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CDK16 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76536 PCTAIRE1 Protein, Human (sf9, GST) Q00536-1 (M1-F496) ≥95%

CDK16 抗体

目录号 产品名 应用 反应物种
HY-P80612 CDK16 Antibody (YA515) WB Human

关联疾病

疾病名称 别名
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-X0150 JSH-150 Inhibitor 98.66% 否
HY-148062 RSS0680 99.85% 否
HY-148063 DB0614 98.80% 否
HY-160213 JA397 Inhibitor / 否
HY-X0009A JSH-009 dimaleate Inhibitor / 否
HY-146680 FLT3/ITD-IN-4 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CDK16 RGD RGD:620584
Felis catus CDK16 VGNC VGNC:68735
Mus musculus CDK16 MGD MGI:97516
Bos taurus CDK16 VGNC VGNC:27119
Macaca mulatta CDK16 VGNC VGNC:71160
Canis familiaris CDK16 VGNC VGNC:39048
Others CDK16 NCBI
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