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  2. GMIP - GEM interacting protein Gene

GMIP - GEM interacting protein Gene

中文名称:GEM 相互作用蛋白

种属: Homo sapiens

同用名: ARHGAP46

基因 ID: 51291 | 基因类型: protein coding

关于 GMIP

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:19,629,476-19,643,657 (from NCBI)

This gene has 8 transcripts (splice variants), 195 orthologues and 2 paralogues. Broad expression in spleen (RPKM 20.3), bone marrow (RPKM 16.1) and 21 other tissues.

功能概要

该基因编码 Rho/Rac/Cdc42 样 GTP 酶激活蛋白的 ARHGAP 家族成员。编码的蛋白质通过其 N 末端结构域与 Ras 相关蛋白 Gem 相互作用。另外,它通过 RhoGAP 结构域与 RhoA 相互作用,并刺激 RhoA 依赖性 GTPase 活性。可变剪接导致多个转录本变体。[RefSeq 提供,2014 年 1 月]

This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GMIP 基因产物(3)

mRNA Protein Name
NM_001288998.2 NP_001275927.1 GEM-interacting protein isoform 2
NM_001288999.2 NP_001275928.1 GEM-interacting protein isoform 3
NM_016573.4 NP_057657.2 GEM-interacting protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity IDA
IDA: 通过直接分析推断
12093360 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12093360 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
12093360 GOA
involved in negative regulation of GTPase activity IDA
IDA: 通过直接分析推断
12093360 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GMIP 蛋白结构

RhoGAP

RhoGAP: RhoGAP domain (565 - 724)

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  • 970 a.a.
蛋白主名 其他名称

GEM-interacting protein

直系同源

种属 基因名 来源 基因 ID
Bos taurus GMIP VGNC VGNC:29436
Felis catus GMIP VGNC VGNC:62607
Macaca mulatta GMIP VGNC VGNC:72999
Mus musculus GMIP MGD MGI:1926066
Rattus norvegicus GMIP RGD RGD:1565577
Canis familiaris GMIP VGNC VGNC:41289