ANAPC7 - anaphase promoting complex subunit 7 Gene

中文名称：后期促进复合亚基 7

种属: Homo sapiens

同用名: APC7; FERBON

关于 ANAPC7

功能概要

该基因编码含有后期促进复合物/细胞周期体 (APC/C) 组分的四肽重复序列，这是一种大型 E3 泛素连接酶，通过靶向许多细胞周期调节因子 (例如用于 26S 蛋白酶体介导的 B 型细胞周期蛋白) 来控制细胞周期进程通过泛素化降解。编码的蛋白质是 APC/C 的适当蛋白质泛素化功能以及 APC/C 与某些转录共激活因子相互作用所必需的。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 11 月]

This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin Ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]