PRRX2 - paired related homeobox 2 Gene

中文名称：配对相关同源框 2

种属: Homo sapiens

同用名: PMX2; PRX2

关于 PRRX2

功能概要

由该基因编码的 DNA 相关蛋白是同源框蛋白配对家族的成员。表达局限于增殖的胎儿成纤维细胞和发育中的真皮层，在成人皮肤中表达下调。该基因在胎儿而非成人伤口愈合过程中表达增加表明可能在控制哺乳动物真皮再生和防止疤痕反应形成的机制中发挥作用。表达模式提供的证据与胎儿皮肤发育中的作用和细胞增殖中的可能作用一致。[RefSeq 提供，2008 年 7 月]

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008]