2. Gene
  3. PDE8A - phosphodiesterase 8A Gene

PDE8A - phosphodiesterase 8A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 8A

种属: Homo sapiens

同用名: HsT19550

基因 ID: 5151 | 基因类型: protein coding

关于 PDE8A

Cytogenetic location: 15q25.3 Genomic coordinates (GRCh38): 15:84,980,467-85,139,142 (from NCBI)

This gene has 16 transcripts (splice variants), 220 orthologues and 20 paralogues. Ubiquitous expression in colon (RPKM 9.5), kidney (RPKM 8.2) and 25 other tissues.

功能概要

该基因编码的蛋白质属于环核苷酸磷酸二酯酶 (PDE) 家族和 PDE8 亚家族。该 PDE 水解第二信使 cAMP，它是许多细胞对细胞外信号反应的调节剂和介体。因此，通过调节 cAMP 的细胞浓度，这种蛋白质在许多重要的生理过程中起着关键作用。已发现该基因编码不同亚型的选择性剪接转录变体。[RefSeq 提供，2011 年 7 月]

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

PDE8A 基因产物(15)

mRNA Protein Name
XM_047432656.1 XP_047288612.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1
NM_001243137.2 NP_001230066.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 3
NM_173456.1
XM_011521668.3 XP_011519970.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X6
NM_173455.1
NM_173454.1 NP_775656.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 2
XM_047432659.1 XP_047288615.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X5
XM_047432658.1 XP_047288614.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3
XR_007064457.1
XM_047432657.1 XP_047288613.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2
XM_017022310.3 XP_016877799.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X4
XM_047432661.1 XP_047288617.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X8
XM_047432660.1 XP_047288616.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X7
NM_002605.3 NP_002596.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 1
NM_173457.1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3',5'-cyclic-AMP phosphodiesterase activity IMP
IMP: 通过突变表型推断
9618252 GOA
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
9618252 GOA
enables kinase binding IPI
IPI: 通过物理相互作用推断
23509299 GOA
enables protein kinase activator activity IMP
IMP: 通过突变表型推断
23509299 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to epidermal growth factor stimulus IMP
IMP: 通过突变表型推断
23509299 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
23509299 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDE8A 蛋白结构

Response_reg

Response_reg: Response regulator receiver domain (83 - 197)

PAS

PAS: PAS fold (219 - 324)

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (555 - 809)

  • 0
  • 200
  • 400
  • 600
  • 829 a.a.
蛋白主名 其他名称

high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

cAMP-specific cyclic nucleotide phosphodiesterase 8A

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15426 PF-04957325 Inhibitor 99.55% 否
HY-134937 BC8-15 Inhibitor / 否
HY-RS10242 PDE8A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS10243 Pde8a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS10244 Pde8a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PDE8A VGNC VGNC:44365
Bos taurus PDE8A VGNC VGNC:32687
Felis catus PDE8A VGNC VGNC:68766
Mus musculus PDE8A MGD MGI:1277116
Macaca mulatta PDE8A VGNC VGNC:75924
Rattus norvegicus PDE8A RGD RGD:735125
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