2. Gene
  3. ETV7 - ETS variant transcription factor 7 Gene

ETV7 - ETS variant transcription factor 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：ETS 变体转录因子 7

种属: Homo sapiens

同用名: TEL2; TELB; TEL-2

基因 ID: 51513 | 基因类型: protein coding

关于 ETV7

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:36,354,088-36,387,669 (from NCBI)

This gene has 8 transcripts (splice variants), 161 orthologues and 28 paralogues. Broad expression in duodenum (RPKM 4.4), small intestine (RPKM 3.6) and 19 other tissues.

功能概要

该基因编码的蛋白质属于转录因子 ETS 家族，是一大类进化上保守的转录调控因子，在细胞发育和分化的多种过程中发挥重要作用，并参与肿瘤发生。这种蛋白质主要在造血组织中表达。已针对该基因描述了几种编码不同亚型的可变剪接转录物变体 (PMID:11108721) 。[RefSeq 提供，2011 年 5 月]

The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721).[provided by RefSeq, May 2011]

ETV7 基因产物(8)

mRNA Protein Name
NM_001207035.2 NP_001193964.1 transcription factor ETV7 isoform 2
NM_001207036.2 NP_001193965.1 transcription factor ETV7 isoform 3
NM_001207037.2 NP_001193966.1 transcription factor ETV7 isoform 4
NM_001207038.2 NP_001193967.1 transcription factor ETV7 isoform 5
NM_001207039.2 NP_001193968.1 transcription factor ETV7 isoform 6
NM_001207040.2 NP_001193969.1 transcription factor ETV7 isoform 7
NM_001207041.2 NP_001193970.1 transcription factor ETV7 isoform 8
NM_016135.4 NP_057219.1 transcription factor ETV7 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
11108721 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
11108721 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12588862 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11108721 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ETV7 蛋白结构

SAM_PNT

SAM_PNT: Sterile alpha motif (SAM)/Pointed domain (47 - 116)

Ets

Ets: Ets-domain (225 - 306)

  • 0
  • 100
  • 200
  • 300
  • 341 a.a.
蛋白主名 其他名称

transcription factor ETV7

ETS-related protein Tel2

关联疾病

疾病名称 别名
Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Primitive Neuroectodermal Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Ewing Family Of Tumors

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral
Progressive Myoclonus Epilepsy 7

Epm7

Meak

Myoclonus Epilepsy And Ataxia Due To Potassium Channel Mutation

Pme Type 7

Progressive Myoclonic Epilepsy Due To Kv3.1 Deficiency

Progressive Myoclonus Epilepsy Type 7
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04570 ETV7 Human Pre-designed siRNA Set A Pre-designed Set / 否
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