PDE1B - phosphodiesterase 1B Gene

中文名称：磷酸二酯酶 1B

种属: Homo sapiens

同用名: PDE1B1; PDES1B; HEL-S-79p

关于 PDE1B

功能概要

该基因编码的蛋白质属于环核苷酸磷酸二酯酶 (PDE) 家族和 PDE1 亚家族。 PDE1 家族的成员是钙调蛋白依赖性 PDE，由钙-钙调蛋白复合物刺激。此 PDE 对第二信使 cAMP 和 cGMP 具有双重特异性，并优先选择 cGMP 作为底物。 cAMP 和 cGMP 作为许多重要生理过程的关键调节剂发挥作用。已针对该基因描述了编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 7 月]

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]