2. Gene
  3. ZC3HC1 - zinc finger C3HC-type containing 1 Gene

ZC3HC1 - zinc finger C3HC-type containing 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含锌指 C3HC 型 1

种属: Homo sapiens

同用名: NIPA; HSPC216

基因 ID: 51530 | 基因类型: protein coding

关于 ZC3HC1

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,018,286-130,051,451 (from NCBI)

This gene has 12 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in testis (RPKM 3.8), lymph node (RPKM 2.0) and 25 other tissues.

功能概要

该基因编码一种含有 F-box 的蛋白质，该蛋白质是调节细胞分裂开始的 SCF 型 E3 泛素连接酶复合物的组成部分。细胞周期中的 G2/M 转换需要蛋白质细胞周期蛋白 B1 和细胞周期蛋白依赖性激酶 1 的相互作用。活化的泛素连接酶复合物靶向蛋白质细胞周期蛋白 B1 进行降解，从而阻止这种向有丝分裂的转变。[RefSeq 提供，2013 年 8 月]

This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin Ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin Ligase complex targets the protein cyclin B1 for degradation, preventing this transition to Mitosis. [provided by RefSeq, Aug 2013]

ZC3HC1 基因产物(4)

mRNA Protein Name
NM_001282190.2 NP_001269119.1 zinc finger C3HC-type protein 1 isoform 2
NM_001282191.1 NP_001269120.1 zinc finger C3HC-type protein 1 isoform 3
NM_001363701.1 NP_001350630.1 zinc finger C3HC-type protein 1 isoform 4
NM_016478.5 NP_057562.3 zinc finger C3HC-type protein 1 isoform 1

ZC3HC1 蛋白结构

zf-C3HC

zf-C3HC: C3HC zinc finger-like (73 - 199)

Rsm1

Rsm1: Rsm1-like (248 - 332)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 502 a.a.
蛋白主名 其他名称

zinc finger C3HC-type protein 1

nuclear-interacting partner of ALK

hematopoietic stem/progenitor cell protein 216

关联疾病

疾病名称 别名
Immunodeficiency 30

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12rb1 Deficiency

IMD30

Il12rb1 Deficiency

Mendelian Susceptibility To Interleukin 12 Receptor Beta 1 Deficiency

Msmd Due To Complete Il12rb1 Deficiency

Msmd Due To Complete Interleukin 12 Receptor Beta 1 Deficiency

Il-12râ1 Deficiency

Mendelian Susceptibility To Mycobacterial Infections Due To Il12 Deficiency

Immunodeficiency, Type 30
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15998 ZC3HC1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ZC3HC1 MGD MGI:1916023
Felis catus ZC3HC1 VGNC VGNC:67192
Macaca mulatta ZC3HC1 VGNC VGNC:79827
Rattus norvegicus ZC3HC1 RGD RGD:1561099
Bos taurus ZC3HC1 VGNC VGNC:37113
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