2. Gene
  3. CPSF3 - cleavage and polyadenylation specific factor 3 Gene

CPSF3 - cleavage and polyadenylation specific factor 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：裂解和聚腺苷酸化特异性因子 3

种属: Homo sapiens

同用名: CPSF73; NEDMHS; CPSF-73; NEDMHSN

基因 ID: 51692 | 基因类型: protein coding

关于 CPSF3

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:9,423,654-9,473,101 (from NCBI)

This gene has 5 transcripts (splice variants), 245 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 20.7), lymph node (RPKM 8.6) and 24 other tissues.

功能概要

该基因编码金属-β-内酰胺酶家族的成员。编码的蛋白质是切割和聚腺苷酸化特异性因子的 73kDa 亚基，作为核酸内切酶起作用，可在聚腺苷酸化之前识别前体 mRNA 3'-切割位点 AAUAAA。在组蛋白 3' 端前体 mRNA 加工过程中，它还在前体 mRNA 序列 ACCCA 之后进行切割。[RefSeq 提供，2012 年 10 月]

This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an Endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012]

CPSF3 基因产物(5)

mRNA Protein Name
NM_001321833.2 NP_001308762.1 cleavage and polyadenylation specificity factor subunit 3 isoform b
NM_001321834.2 NP_001308763.1 cleavage and polyadenylation specificity factor subunit 3 isoform b
NM_001321835.2 NP_001308764.1 cleavage and polyadenylation specificity factor subunit 3 isoform c
NM_001321836.2 NP_001308765.1 cleavage and polyadenylation specificity factor subunit 3 isoform d
NM_016207.4 NP_057291.1 cleavage and polyadenylation specificity factor subunit 3 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA endonuclease activity IMP
IMP: 通过突变表型推断
30507380 GOA
enables metal ion binding IMP
IMP: 通过突变表型推断
30507380 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18288197 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IDA
IDA: 通过直接分析推断
8929409 GOA
involved in mRNA 3'-end processing IMP
IMP: 通过突变表型推断
30507380 GOA
involved in mRNA 3'-end processing by stem-loop binding and cleavage IDA
IDA: 通过直接分析推断
18688255 GOA
involved in positive regulation of G1/S transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
30507380 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of mRNA cleavage and polyadenylation specificity factor complex IDA
IDA: 通过直接分析推断
8929409 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CPSF3 蛋白结构

Lactamase_B

Lactamase_B: Metallo-beta-lactamase superfamily (21 - 191)

Beta-Casp

Beta-Casp: Beta-Casp domain (246 - 366)

RMMBL

RMMBL: Zn-dependent metallo-hydrolase RNA specificity domain (381 - 421)

CPSF73-100_C

CPSF73-100_C: Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term (477 - 683)

  • 0
  • 200
  • 400
  • 600
  • 684 a.a.
蛋白主名 其他名称

cleavage and polyadenylation specificity factor subunit 3

cleavage and polyadenylation specific factor 3, 73kDa

CPSF3 抗体

目录号 产品名 应用 反应物种
HY-P86821 CPSF73 Antibody (YA6514) WB, IHC-P Human, Mouse, Rat

关联疾病

疾病名称 别名
Neurodevelopmental Disorder With Microcephaly, Hypotonia, Nystagmus, And Seizures

NEDMHS
Neurodevelopmental Disorder With Hypotonia, Microcephaly, And Seizures

NEDHYMS
Oculopharyngeal Muscular Dystrophy

OPMD

Muscular Dystrophy, Oculopharyngeal

Dystrophy, Oculopharyngeal Muscular

Oculopharyngeal Dystrophy

Progressive Muscular Dystrophy, Oculopharyngeal Type

Muscular Dystrophy Oculopharyngeal

Dystrophy, Muscular, Oculopharyngeal
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-110133 JTE-607 Inhibitor 99.27% Phase 2
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03118 CPSF3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-110133A JTE-607 free base Inhibitor / 否
HY-RS19423 Cpsf3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS25914 Cpsf3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CPSF3 VGNC VGNC:61141
Rattus norvegicus CPSF3 RGD RGD:1305767
Macaca mulatta CPSF3 VGNC VGNC:106142
Mus musculus CPSF3 MGD MGI:1859328
Bos taurus CPSF3 VGNC VGNC:27672
Canis familiaris CPSF3 VGNC VGNC:39575
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