2. Gene
  3. Bok - BCL2-related ovarian killer Gene

Bok - BCL2-related ovarian killer Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: mtd; matador

基因 ID: 51800 | 基因类型: protein coding

关于 Bok

功能概要

Enables protein homodimerization activity; signaling receptor binding activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; ion homeostasis; and regulation of programmed cell death. Acts upstream of or within neuron apoptotic process. Located in several cellular components, including bounding membrane of organelle; mitochondrial membrane; and trans-Golgi network membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; gut; retina; and vibrissa dermal component. Orthologous to human BOK (BCL2 family Apoptosis regulator BOK). [provided by Alliance of Genome Resources, Apr 2022]

Bok 基因产物(1)

mRNA Protein Name
NM_016778.3 NP_058058.1 bcl-2-related ovarian killer protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23884412 MGI
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
23429263 MGI
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
23884412 MGI
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
26949185 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IMP
IMP: 通过突变表型推断
26015568 MGI
involved in cellular component disassembly involved in execution phase of apoptosis IDA
IDA: 通过直接分析推断
23429263 MGI
involved in negative regulation of mitochondrial depolarization IMP
IMP: 通过突变表型推断
27098698 MGI
involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IMP
IMP: 通过突变表型推断
27098698 MGI
involved in negative regulation of necroptotic process IMP
IMP: 通过突变表型推断
27098698 MGI
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
27098698 MGI
acts upstream of or within neuron apoptotic process IDA
IDA: 通过直接分析推断
9535847 MGI
involved in positive regulation of PERK-mediated unfolded protein response IMP
IMP: 通过突变表型推断
26015568 MGI
involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
26949185 MGI
involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
26015568 MGI
involved in positive regulation of intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
23429263 MGI
involved in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA
IDA: 通过直接分析推断
26949185 MGI
involved in protein complex oligomerization IDA
IDA: 通过直接分析推断
26949185 MGI
involved in regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
27098698 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cis-Golgi network membrane IDA
IDA: 通过直接分析推断
23429263 MGI
located in early endosome membrane IDA
IDA: 通过直接分析推断
23429263 MGI
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
23429263 MGI
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
23429263 MGI
located in recycling endosome membrane IDA
IDA: 通过直接分析推断
23429263 MGI
located in trans-Golgi network membrane IDA
IDA: 通过直接分析推断
23429263 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

bcl-2-related ovarian killer protein

apoptosis activator Mtd

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01570 BOK Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18323 Bok Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24801 Bok Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bok NCBI NCBI:666
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