FXYD4 - FXYD domain containing ion transport regulator 4 Gene

中文名称：含 FXYD 域离子传输调节因子 4

种属: Homo sapiens

同用名: CHIF

关于 FXYD4

功能概要

该基因编码一个小膜蛋白家族的成员，该家族共享一个 35 个氨基酸的特征序列域，从序列 PFXYD 开始，包含 7 个不变氨基酸和 6 个高度保守的氨基酸。该家族批准的人类基因命名法是含有离子传输调节剂的 FXYD 结构域。 FXYD4 最初因通道诱导因子而命名为 CHIF，已被证明可以调节 Na,K-ATPase 的特性，FXYD2 (也称为 Na,K-ATPase 的伽马亚基) 和 FXYD7 也是如此。已经为 FXYD4 和两个家族成员 (FXYD1 和 FXYD2) 建立了跨膜拓扑结构，N 端位于细胞外，C 端位于膜的细胞质侧。已发现编码相同蛋白质的可变剪接转录变体。[RefSeq 提供，2010 年 5 月]

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved Amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, May 2010]