2. Gene
  3. GPR88 - G protein-coupled receptor 88 Gene

GPR88 - G protein-coupled receptor 88 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 88

种属: Homo sapiens

同用名: STRG; COCPMR

基因 ID: 54112 | 基因类型: protein coding

关于 GPR88

Cytogenetic location: 1p21.2 Genomic coordinates (GRCh38): 1:100,538,139-100,542,021 (from NCBI)

This gene has 1 transcript (splice variant), 147 orthologues, 33 paralogues and is associated with 1 phenotype. Biased expression in spleen (RPKM 5.3), liver (RPKM 2.4) and 4 other tissues.

功能概要

由该基因编码的蛋白质是一种 G 蛋白偶联受体，几乎完全存在于纹状体中，纹状体是一种控制运动功能和认知的大脑结构。该基因的缺陷与舞蹈病、言语延迟和学习困难以及一些神经精神疾病有关。[RefSeq 提供，2017 年 3 月]

The protein encoded by this gene is a G protein-coupled receptor found almost exclusively in the striatum, a brain structure that controls motor function and cognition. Defects in this gene have been associated with chorea, speech delay, and learning difficulties, as well as some neuropsychiatric disorders. [provided by RefSeq, Mar 2017]

GPR88 基因产物(1)

mRNA Protein Name
NM_022049.3 NP_071332.2 probable G-protein coupled receptor 88
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta2-adrenergic receptor activity IDA
IDA: 通过直接分析推断
23936473 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
35501348 GOA
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
23936473 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in ciliary membrane IDA
IDA: 通过直接分析推断
23936473 GOA
located in cilium IDA
IDA: 通过直接分析推断
28154160 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPR88 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (49 - 336)

  • 0
  • 100
  • 200
  • 300
  • 384 a.a.
蛋白主名 其他名称

probable G-protein coupled receptor 88

striatum-specific G-protein coupled receptor

关联疾病

疾病名称 别名
Choreatic Disease

Chorea

Hereditary Chorea
Chorea, Childhood-Onset, With Psychomotor Retardation

COCPMR

Chorea
Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2

Acromegaly Due To Pituitary Adenoma 2

Acromegaly, X-Linked

Growth Hormone Secreting Pituitary Adenoma 2

Pituitary Adenoma, Growth Hormone-Secreting, 2

Pituitary Adenoma 2, Gh-Secreting

Gh-Secreting Pituitary Adenoma 2

X-Linked Acromegaly

Adenoma, Pituitary, Growth Hormone-Secreting, Type 2
Dyskinetic Cerebral Palsy

Athetoid Cerebral Palsy

Athetoid Dyskinetic Cerebral Palsy

Cerebral Palsy Athetoid

Cerebral Palsy Dyskinetic

Athetoid Cerebral Paralysis

Dyskinetic Cerebral Paralysis

Vogt Disease

Athetoid Cerebrum Palsy

Double Athetosis Syndrome

État Marbré
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100013A1 (1R,2R)-2-PCCA hydrochloride 98.08% 否
HY-112612A RTI-13951-33 hydrochloride 98.56% 否
HY-100013C 2-PCCA hydrochloride 99.63% 否
HY-156771 GPR88-IN-1 Inhibitor 99.54% 否
HY-156772 GPR88 agonist 2 Agonist 99.57% 否
HY-112612 RTI-13951-33 / 否
HY-100013B1 (1S,2S)-2-PCCA hydrochloride Control 99.65% 否
HY-162660 BI-9508 Agonist / 否
HY-167856 RTI-122 Agonist / 否
HY-163096 GPR88 agonist 3 Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GPR88 MGD MGI:1927653
Canis familiaris GPR88 VGNC VGNC:54029
Rattus norvegicus GPR88 RGD RGD:61921
Bos taurus GPR88 VGNC VGNC:29604
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