SMOX - spermine oxidase Gene

中文名称：精胺氧化酶

种属: Homo sapiens

同用名: PAO; SMO; PAO1; PAOH; PAO-1; PAOH1; C20orf16

关于 SMOX

功能概要

多胺是普遍存在的聚阳离子烷基胺，包括精胺、亚精胺、腐胺和胍丁胺。这些分子参与广泛的细胞功能，包括细胞周期调节、清除活性氧和控制基因表达。这些分子还通过调节细胞表面受体活性、参与细胞内信号通路以及它们作为神经递质的推定作用在神经传递中发挥重要作用。该基因编码一种含有 FAD 的酶，该酶催化精胺氧化为精胺并继而产生过氧化氢。已经为该基因鉴定了编码不同同工酶的多个转录物变体，其中一些未能证明对天然多胺底物具有显着的氧化酶活性。表征的同工酶具有独特的生化特征和底物特异性，表明多胺分解代谢中存在额外的复杂性水平。[RefSeq 提供，2012 年 7 月]

Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging Reactive Oxygen Species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012]