ING3 - inhibitor of growth family member 3 Gene

中文名称：生长抑制因子家族成员 3

种属: Homo sapiens

同用名: Eaf4; ING2; MEAF4; p47ING3

关于 ING3

功能概要

该基因编码的蛋白与 ING1 相似，是一种抑癌蛋白，可与 TP53 相互作用，抑制细胞生长，诱导细胞凋亡。这种蛋白质包含一个 PHD 指，这是参与染色质重塑的蛋白质中的常见基序。该基因可以激活 p53 反式激活的启动子，包括 p21/waf1 和 Bax 的启动子。该基因的过度表达已被证明可抑制细胞生长并诱导细胞凋亡。在头颈癌中检测到该基因的等位基因丢失和表达减少。已观察到编码不同同种型的两种选择性剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce Apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and Bax. Overexpression of this gene has been shown to inhibit cell growth and induce Apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]