DDX56 - DEAD-box helicase 56 Gene

中文名称：死盒解旋酶 56

种属: Homo sapiens

同用名: DDX21; DDX26; NOH61

关于 DDX56

功能概要

该基因编码 DEAD box 蛋白家族的一个成员。以保守基序 Asp-Glu-Ala-Asp (DEAD) 为特征的 DEAD 盒蛋白是推定的 RNA 解旋酶。它们涉及许多涉及 RNA 二级结构改变的细胞过程，例如翻译起始、核和线粒体剪接以及核糖体和剪接体组装。根据它们的分布模式，该家族的一些成员被认为参与了胚胎发生、精子发生以及细胞生长和分裂。由该基因编码的蛋白质在多核苷酸存在的情况下显示出 ATP 酶活性，并与核质 65S 前核糖体颗粒结合。该基因可能参与核糖体合成，很可能是在 60S 核糖体大亚基的组装过程中。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2012 年 3 月]

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene shows ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles. This gene may be involved in ribosome synthesis, most likely during assembly of the large 60S ribosomal subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]