2. Gene
  3. Parp14 - poly (ADP-ribose) polymerase family, member 14 Gene

Parp14 - poly (ADP-ribose) polymerase family, member 14 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：聚 (ADP-核糖) 聚合酶家族，成员 14

种属: Mus musculus

同用名: ARTD8; CoaSt6; mKIAA1268; 1600029O10Rik

基因 ID: 547253 | 基因类型: protein coding

关于 Parp14

Chromosome 16: 35,653,244-35,691,914 reverse strand.GRCm39:CM001009.3

This gene has 3 transcripts (splice variants), 295 orthologues, 7 paralogues and is associated with 7 phenotypes. Broad expression in large intestine adult (RPKM 6.), bladder adult (RPKM 4.4) and 21 other tissues.

功能概要

预计该基因编码的蛋白可启动多项功能，包括 NAD+ 绑定活动；戊糖基转移酶活性；和转录辅阻遏物活性。参与干扰素-γ 介导的信号通路的负调节和白细胞介素 4 介导的信号通路的正调节。位于细胞质中。在 Peyer's patch 中表达；淋巴系统；肠;和泌尿生殖窦。与人类 PARP14（聚（ADP-核糖）聚合酶家族成员 14）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including NAD+ binding activity; pentosyltransferase activity; and transcription corepressor activity. Involved in negative regulation of interferon-gamma-mediated signaling pathway and positive regulation of interleukin-4-mediated signaling pathway. Located in cytoplasm. Is expressed in Peyer's patch; hemolymphoid system; intestine; and urogenital sinus. Orthologous to human PARP14 (poly(ADP-ribose) polymerase family member 14). [provided by Alliance of Genome Resources, Apr 2022]

Parp14 基因产物(1)

mRNA Protein Name
NM_001039530.3 NP_001034619.2 protein mono-ADP-ribosyltransferase PARP14
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16537510 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of type II interferon-mediated signaling pathway IMP
IMP: 通过突变表型推断
27796300 MGI
involved in positive regulation of interleukin-4-mediated signaling pathway IMP
IMP: 通过突变表型推断
27796300 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
23473667 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Parp14 蛋白结构

RRM1_PAR14

RRM1_PAR14: cd12300 (5 - 86)

RRM_SF

RRM_SF: cl17169 (225 - 299)

Macro_Af1521_BAL-like

Macro_Af1521_BAL-like: cd02907 (811 - 969)

Macro_BAL-like

Macro_BAL-like: cd02903 (1021 - 1200)

Macro_BAL-like

Macro_BAL-like: cd02903 (1230 - 1396)

TCCD_inducible_PARP_like

TCCD_inducible_PARP_like: cd01439 (1694 - 1814)

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  • 1817 a.a.
蛋白主名 其他名称

protein mono-ADP-ribosyltransferase PARP14

ADP-ribosyltransferase diphtheria toxin-like 8

PARP-14

collaborator of STAT6

poly [ADP-ribose] polymerase 14

相关产品

Pre-clinical Phase
生物活性分子 (16)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-136979 RBN012759 Inhibitor 99.33% 否
HY-148566 OUL232 Inhibitor 99.86% 否
HY-150207 RBN-3143 Inhibitor 99.29% 否
HY-117889 PARP14 inhibitor H10 Inhibitor / 否
HY-148754 PARP10-IN-3 Inhibitor 98.89% 否
HY-108708 GeA-69 Inhibitor 99.91% 否
HY-143338 ART-IN-1 Inhibitor 98.91% 否
HY-121719 TIQ-A Inhibitor 99.85% 否
HY-173679 RBN012811 Degrader / 否
HY-155993 YCH1899 Inhibitor 99.39% 否
HY-148753 PARP10-IN-2 Inhibitor 98.02% 否
HY-172806 PARP14 inhibitor 1 Inhibitor / 否
HY-176456 PARP14 inhibitor 2 Inhibitor / 否
HY-W294889 OUL245 Inhibitor / 否
HY-148709 ARTD10/PARP10-IN-1 Inhibitor / 否
HY-148710 ARTD10/PARP10-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Parp14 NCBI NCBI:54625
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