2. Gene
  3. PXK - PX domain containing serine/threonine kinase like Gene

PXK - PX domain containing serine/threonine kinase like Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含丝氨酸/苏氨酸激酶的 PX 结构域

种属: Homo sapiens

同用名: SLOB; MONAKA

基因 ID: 54899 | 基因类型: protein coding

关于 PXK

Cytogenetic location: 3p14.3 Genomic coordinates (GRCh38): 3:58,332,892-58,426,127 (from NCBI)

This gene has 14 transcripts (splice variants), 207 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in thyroid (RPKM 17.1), brain (RPKM 11.4) and 24 other tissues.

功能概要

该基因编码含有 phox (PX) 结构域的蛋白质，该蛋白质可能参与突触传递和配体诱导的表皮生长因子的内化和降解。该基因的变异可能与系统性红斑狼疮 (SLE) 的易感性有关。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 1 月]

This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

PXK 基因产物(58)

mRNA Protein Name
NM_001289095.2 NP_001276024.1 PX domain-containing protein kinase-like protein isoform b
NM_001289096.2 NP_001276025.1 PX domain-containing protein kinase-like protein isoform c
NM_001289098.2 NP_001276027.1 PX domain-containing protein kinase-like protein isoform d
NM_001289099.2 NP_001276028.1 PX domain-containing protein kinase-like protein isoform e
NM_001289100.2 NP_001276029.1 PX domain-containing protein kinase-like protein isoform f
NM_001289101.2 NP_001276030.1 PX domain-containing protein kinase-like protein isoform g
NM_001349488.2 NP_001336417.1 PX domain-containing protein kinase-like protein isoform d
NM_001349489.2 NP_001336418.1 PX domain-containing protein kinase-like protein isoform e
NM_001349490.2 NP_001336419.1 PX domain-containing protein kinase-like protein isoform f
NM_001349491.2 NP_001336420.1 PX domain-containing protein kinase-like protein isoform g
NM_001349492.2 NP_001336421.1 PX domain-containing protein kinase-like protein isoform h
NM_001349493.2 NP_001336422.1 PX domain-containing protein kinase-like protein isoform i
NM_001349494.2 NP_001336423.1 PX domain-containing protein kinase-like protein isoform j
NM_001349495.2 NP_001336424.1 PX domain-containing protein kinase-like protein isoform k
NM_001349496.2 NP_001336425.1 PX domain-containing protein kinase-like protein isoform jj
NM_001349497.2 NP_001336426.1 PX domain-containing protein kinase-like protein isoform l
NM_001349498.1 NP_001336427.1 PX domain-containing protein kinase-like protein isoform m
NM_001349499.2 NP_001336428.1 PX domain-containing protein kinase-like protein isoform n
NM_001349500.2 NP_001336429.1 PX domain-containing protein kinase-like protein isoform o
NM_001349501.2 NP_001336430.1 PX domain-containing protein kinase-like protein isoform p
NM_001349502.2 NP_001336431.1 PX domain-containing protein kinase-like protein isoform q
NM_001349503.2 NP_001336432.1 PX domain-containing protein kinase-like protein isoform r
NM_001349504.2 NP_001336433.1 PX domain-containing protein kinase-like protein isoform kk
NM_001349506.2 NP_001336435.1 PX domain-containing protein kinase-like protein isoform kk
NM_001349507.2 NP_001336436.1 PX domain-containing protein kinase-like protein isoform r
NM_001349508.2 NP_001336437.1 PX domain-containing protein kinase-like protein isoform s
NM_001349509.2 NP_001336438.1 PX domain-containing protein kinase-like protein isoform s
NM_001349510.2 NP_001336439.1 PX domain-containing protein kinase-like protein isoform t
NM_001349511.2 NP_001336440.1 PX domain-containing protein kinase-like protein isoform u
NM_001349512.2 NP_001336441.1 PX domain-containing protein kinase-like protein isoform ll
NM_001349513.2 NP_001336442.1 PX domain-containing protein kinase-like protein isoform mm
NM_001349514.2 NP_001336443.1 PX domain-containing protein kinase-like protein isoform nn
NM_001349515.2 NP_001336444.1 PX domain-containing protein kinase-like protein isoform v
NM_001349516.2 NP_001336445.1 PX domain-containing protein kinase-like protein isoform oo
NM_001349517.2 NP_001336446.1 PX domain-containing protein kinase-like protein isoform pp
NM_001349518.2 NP_001336447.1 PX domain-containing protein kinase-like protein isoform w
NM_001349519.2 NP_001336448.1 PX domain-containing protein kinase-like protein isoform x
NM_001349520.2 NP_001336449.1 PX domain-containing protein kinase-like protein isoform x
NM_001349521.2 NP_001336450.1 PX domain-containing protein kinase-like protein isoform qq
NM_001349522.2 NP_001336451.1 PX domain-containing protein kinase-like protein isoform y
NM_001349524.2 NP_001336453.1 PX domain-containing protein kinase-like protein isoform z
NM_001349525.2 NP_001336454.1 PX domain-containing protein kinase-like protein isoform aa
NM_001349526.2 NP_001336455.1 PX domain-containing protein kinase-like protein isoform bb
NM_001349527.2 NP_001336456.1 PX domain-containing protein kinase-like protein isoform cc
NM_001349528.2 NP_001336457.1 PX domain-containing protein kinase-like protein isoform dd
NM_001349529.2 NP_001336458.1 PX domain-containing protein kinase-like protein isoform dd
NM_001349530.2 NP_001336459.1 PX domain-containing protein kinase-like protein isoform ee
NM_001349531.2 NP_001336460.1 PX domain-containing protein kinase-like protein isoform rr
NM_001349532.2 NP_001336461.1 PX domain-containing protein kinase-like protein isoform ff
NM_001349533.2 NP_001336462.1 PX domain-containing protein kinase-like protein isoform gg
NM_001349534.2 NP_001336463.1 PX domain-containing protein kinase-like protein isoform gg
NM_001349535.2 NP_001336464.1 PX domain-containing protein kinase-like protein isoform hh
NM_001349536.2 NP_001336465.1 PX domain-containing protein kinase-like protein isoform hh
NM_001349537.2 NP_001336466.1 PX domain-containing protein kinase-like protein isoform ss
NM_001349538.2 NP_001336467.1 PX domain-containing protein kinase-like protein isoform ss
NM_001349539.2 NP_001336468.1 PX domain-containing protein kinase-like protein isoform ii
NM_001349540.2 NP_001336469.1 PX domain-containing protein kinase-like protein isoform ii
NM_017771.5 NP_060241.2 PX domain-containing protein kinase-like protein isoform a

PXK 蛋白结构

PX

PX: PX domain (30 - 121)

Pkinase

Pkinase: Protein kinase domain (198 - 351)

WH2

WH2: WH2 motif (546 - 573)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 578 a.a.
蛋白主名 其他名称

PX domain-containing protein kinase-like protein

PX ser/thr kinase v2

PXK 抗体

目录号 产品名 应用 反应物种
HY-P85561 Akt1 Antibody (YA5253) WB Mouse, Transfected

关联疾病

疾病名称 别名
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]
Limited Scleroderma

Limited Cutaneous Systemic Sclerosis

Limited Systemic Sclerosis

Systemic Sclerosis Sine Scleroderma

Crest Syndrome

Limited Cutaneous Systemic Scleroderma

Scleroderma, Limited

Systemic Sclerosis, Limited

Progressive Systemic Sclerosis Sine Scleroderma

Scleroderma, Sine

Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome

Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11481 PXK Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PXK VGNC VGNC:33583
Macaca mulatta PXK VGNC VGNC:76522
Rattus norvegicus PXK RGD RGD:727819
Felis catus PXK VGNC VGNC:64448
Mus musculus PXK MGD MGI:1289230
Canis familiaris PXK VGNC VGNC:45219
Others PXK NCBI
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