2. Gene
  3. HERC6 - HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 Gene

HERC6 - HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：含 HECT 和 RLD 结构域的 E3 泛素蛋白连接酶家族成员 6

种属: Homo sapiens

基因 ID: 55008 | 基因类型: protein coding

关于 HERC6

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:88,378,852-88,443,097 (from NCBI)

This gene has 7 transcripts (splice variants), 98 orthologues and 24 paralogues. Ubiquitous expression in esophagus (RPKM 12.4), gall bladder (RPKM 7.3) and 25 other tissues.

功能概要

HERC6 属于 HERC 泛素连接酶家族，所有家族都包含一个 HECT 结构域和至少 1 个 RCC1 (MIM 179710) 样结构域 (RLD) 。预计 350 个氨基酸的 HECT 结构域会在将泛素转移到底物之前催化硫酯与泛素的形成，并且预计 RLD 会充当小 G 蛋白的鸟嘌呤核苷酸交换因子 (Hochrainer 等人，2005 [ PubMed 15676274]) .[OMIM 提供，2008 年 3 月]

HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

HERC6 基因产物(2)

mRNA Protein Name
NM_001165136.2 NP_001158608.1 probable E3 ubiquitin-protein ligase HERC6 isoform 2
NM_017912.4 NP_060382.3 probable E3 ubiquitin-protein ligase HERC6 isoform 1

HERC6 蛋白结构

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (42 - 90)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (93 - 143)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (148 - 196)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (203 - 251)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (254 - 301)

HECT

HECT: HECT-domain (ubiquitin-transferase) (724 - 1014)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1022 a.a.
蛋白主名 其他名称

probable E3 ubiquitin-protein ligase HERC6

HECT domain and RCC1-like domain-containing protein 6

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06131 HERC6 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16311 Herc6 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus HERC6 VGNC VGNC:29815
Macaca mulatta HERC6 VGNC VGNC:73238
Felis catus HERC6 VGNC VGNC:62800
Mus musculus HERC6 MGD MGI:1914388
Rattus norvegicus HERC6 RGD RGD:1561739
Canis familiaris HERC6 VGNC VGNC:41662
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z