2. Gene
  3. ZWILCH - zwilch kinetochore protein Gene

ZWILCH - zwilch kinetochore protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Zwilch 着丝粒蛋白

种属: Homo sapiens

同用名: KNTC1AP; hZwilch

基因 ID: 55055 | 基因类型: protein coding

关于 ZWILCH

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:66,505,326-66,550,130 (from NCBI)

This gene has 14 transcripts (splice variants) and 197 orthologues. Broad expression in testis (RPKM 32.5), lymph node (RPKM 6.0) and 19 other tissues.

功能概要

参与蛋白质向着丝粒的定位。位于动粒。 RZZ 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Involved in protein localization to kinetochore. Located in kinetochore. Part of RZZ complex. [provided by Alliance of Genome Resources, Apr 2022]

ZWILCH 基因产物(4)

mRNA Protein Name
NM_001287821.2 NP_001274750.1 protein zwilch homolog isoform 2
NM_001287822.2 NP_001274751.1 protein zwilch homolog isoform 2
NM_001287823.2 NP_001274752.1 protein zwilch homolog isoform 2
NM_017975.5 NP_060445.3 protein zwilch homolog isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12686595 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mitotic spindle assembly checkpoint signaling IMP
IMP: 通过突变表型推断
15824131 GOA
involved in protein localization to kinetochore IMP
IMP: 通过突变表型推断
15824131 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RZZ complex IDA
IDA: 通过直接分析推断
20462495 GOA
part of RZZ complex IPI
IPI: 通过物理相互作用推断
25849506 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
12686595 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZWILCH 蛋白结构

Zwilch

Zwilch: RZZ complex, subunit zwilch (31 - 587)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 591 a.a.
蛋白主名 其他名称

protein zwilch homolog

Zwilch, kinetochore associated, homolog

关联疾病

疾病名称 别名
Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia

X-Linked Dominant Chondrodysplasia, Chassaing-Lacombe Type

X-Linked Dominant Chondrodysplasia-Hydrocephaly-Microphthalmia Syndrome

CDP-PBHM

Chondrodysplasia, With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia
Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome

Mva Syndrome

Mosaic Variegated Aneuplody Microcephaly Syndrome

Warburton Anyane Yeboa Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16209 ZWILCH Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ZWILCH RGD RGD:1583880
Felis catus ZWILCH VGNC VGNC:67389
Bos taurus ZWILCH VGNC VGNC:37391
Macaca mulatta ZWILCH VGNC VGNC:79496
Canis familiaris ZWILCH VGNC VGNC:48865
Mus musculus ZWILCH MGD MGI:1915264
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